GENERIC NAME: glipizide
BRAND NAME: Glipizide XL, Glucotrol, Glucotrol XL
DRUG CLASS AND MECHANISM: Glipizide is an oral drug that is used for treating patients with type 2 diabetes. It belongs to the sulfonylurea class of drugs which also includes glimepiride (Amaryl), glyburide (Diabeta, Glynase), tolbutamide and tolazamide. Insulin is a hormone that is made in the pancreas that when released into the blood causes cells in the body to remove sugar (glucose) from the blood and reduces the formation of glucose by the liver. Patients with type 2 diabetes have high glucose (sugar) levels in their blood because the cells in their bodies are resistant to the glucose-removing effect of the insulin, and the liver produces too much glucose. In addition, in type 2 diabetes the pancreas is unable to produce the increased amounts of insulin that are necessary to overcome the resistance. Glipizide reduces blood glucose by stimulating the pancreas to produce more insulin.
Glipizide is not a cure for diabetes.
The FDA approved glipizide in May 1984.
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