Neuromuscular blocking agents may increase the risk of experiencing breathing problems by depressing the activity of respiratory muscles when given with gentamicin.
PREGNANCY: Gentamicin is classified as FDA pregnancy risk category D (There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks). Due to known risk to the fetus gentamicin is usually avoided during pregnancy. Gentamicin should be used cautiously during pregnancy and should only be used if the benefit to the mother outweighs the risk to the fetus.
NURSING MOTHERS: Gentamicin is excreted into human milk. Due to the lack of safety data, gentamicin should be used cautiously in nursing mothers. The benefits of breastfeeding, potential risk of infant drug exposure, and risk of inadequately or untreated infection should all be considered when deciding if gentamicin should be used in females who are breastfeeding.
REFERENCE: FDA Prescribing Information.
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