gentamicin injection (Garamycin)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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Neuromuscular blocking agents may increase the risk of experiencing breathing problems by depressing the activity of respiratory muscles when given with gentamicin.

Loop diuretics such as furosemide (Lasix), bumetanide (Bumex), and torsemide (Demadex) may increase the ototoxicity (hearing impairment) associated with gentamicin treatment.

PREGNANCY: Gentamicin is classified as FDA pregnancy risk category D (There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks). Due to known risk to the fetus gentamicin is usually avoided during pregnancy. Gentamicin should be used cautiously during pregnancy and should only be used if the benefit to the mother outweighs the risk to the fetus.

NURSING MOTHERS: Gentamicin is excreted into human milk. Due to the lack of safety data, gentamicin should be used cautiously in nursing mothers. The benefits of breastfeeding, potential risk of infant drug exposure, and risk of inadequately or untreated infection should all be considered when deciding if gentamicin should be used in females who are breastfeeding.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 12/1/2014

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