gentamicin injection (Garamycin) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DOSING: The dose of gentamicin is usually based on body weight. Total daily dose and duration of treatment depend on the condition or infection being treated. Dose adjustment is necessary for patients who have impaired kidney function. Doses are adjusted to target peak and trough levels.

  • Usual dosage ranges for IM or IV:
  • Conventional dosing: Administer 1 to 2.5 mg/kg/dose every 8-12 hours.
  • Once daily dosing: Administer 4 to 7 mg/kg/day.

DRUG INTERACTIONS: Gentamicin may decrease the effectiveness of the BCG and typhoid vaccine.

Cephalosporins, amphotericin B (Amphocin), cisplatin (Platinol), colistimethate, cyclosporine (Sandimmune), loop diuretics, mannitol (Osmitrol), and vancomycin (Vancocin) may increase the risk of experiencing kidney related side effects of gentamicin.

Nonsteroidal anti-inflammatory agents (NSAIDs) may decrease the kidney excretion or clearance of gentamicin. Examples of NSAIDs are:

Neuromuscular blocking agents may increase the risk of experiencing breathing problems by depressing the activity of respiratory muscles when given with gentamicin.

Medically Reviewed by a Doctor on 12/1/2014

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