gentamicin injection (Garamycin) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DOSING: The dose of gentamicin is usually based on body weight. Total daily dose and duration of treatment depend on the condition or infection being treated. Dose adjustment is necessary for patients who have impaired kidney function. Doses are adjusted to target peak and trough levels.

  • Usual dosage ranges for IM or IV:
  • Conventional dosing: Administer 1 to 2.5 mg/kg/dose every 8-12 hours.
  • Once daily dosing: Administer 4 to 7 mg/kg/day.

DRUG INTERACTIONS: Gentamicin may decrease the effectiveness of the BCG and typhoid vaccine.

Cephalosporins, amphotericin B (Amphocin), cisplatin (Platinol), colistimethate, cyclosporine (Sandimmune), loop diuretics, mannitol (Osmitrol), and vancomycin (Vancocin) may increase the risk of experiencing kidney related side effects of gentamicin.

Nonsteroidal anti-inflammatory agents (NSAIDs) may decrease the kidney excretion or clearance of gentamicin. Examples of NSAIDs are:

Neuromuscular blocking agents may increase the risk of experiencing breathing problems by depressing the activity of respiratory muscles when given with gentamicin.

Loop diuretics such as furosemide (Lasix), bumetanide (Bumex), and torsemide (Demadex) may increase the ototoxicity (hearing impairment) associated with gentamicin treatment.

PREGNANCY: Gentamicin is classified as FDA pregnancy risk category D (There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks). Due to known risk to the fetus gentamicin is usually avoided during pregnancy. Gentamicin should be used cautiously during pregnancy and should only be used if the benefit to the mother outweighs the risk to the fetus.

Medically Reviewed by a Doctor on 12/1/2014


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