PREPARATIONS: Gentamicin sulfate solution for injection: 10, 40 mg/ml
STORAGE: Gentamicin is usually given as an injection at the hospital, clinic, or doctor's office. Patient's using gentamicin solution at home should check with their healthcare provider on details regarding the proper storage of their medication.
DOSING: The dose of gentamicin is usually based on body weight. Total daily dose and duration of treatment depend on the condition or infection being treated. Dose adjustment is necessary for patients who have impaired kidney function. Doses are adjusted to target peak and trough levels.
- Usual dosage ranges for IM or IV:
- Conventional dosing: Administer 1 to 2.5 mg/kg/dose every 8-12 hours.
- Once daily dosing: Administer 4 to 7 mg/kg/day.
DRUG INTERACTIONS: Gentamicin may decrease the effectiveness of the BCG and typhoid vaccine.
Cephalosporins, amphotericin B (Amphocin), cisplatin (Platinol), colistimethate, cyclosporine (Sandimmune), loop diuretics, mannitol (Osmitrol), and vancomycin (Vancocin) may increase the risk of experiencing kidney related side effects of gentamicin.
Nonsteroidal anti-inflammatory agents (NSAIDs) may decrease the kidney excretion or clearance of gentamicin. Examples of NSAIDs are:
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