What is gentamicin-injection, and how does it work (mechanism of action)?

Gentamicin is a broad spectrum aminoglycoside antibiotic that is most effective against aerobic gram-negative rods. Gentamicin is also used in combination with other antibiotics to treat infections caused by gram positive organisms such as Staphylococcus aureus and certain species of streptococci. Additionally, gentamicin is used in combination with a penicillin antibiotic to treat endocarditis (infection of the heart). Gentamicin kills bacteria (bactericidal) by inhibiting the synthesis of bacterial proteins. Gentamicin irreversibly binds to the 30S ribosomal subunits. This binding interferes with the formation of messenger RNA (mRNA) and the subsequent formation of nonfunctional proteins and the eventual death of susceptible bacteria. Gentamicin was approved by the US Food and Drug Administration (FDA) in 1966.

What brand names are available for gentamicin-injection?

Gentamicin Injection, Garamycin

Is gentamicin-injection available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for gentamicin-injection?

Yes

What are the side effects of gentamicin-injection?

Side effects associated with gentamicin use are:

• edema,
• high or low blood pressure,
• kidney problems,
• headache,
• liver problems,
• injection site reactions,
• hair loss,
• itching,
• seizures,
• dizziness,
• depression,
• confusion,
• electrolyte abnormalities,
• nausea,
• vomiting,
• increased salivation,
• visual problems,
• hearing impairment,
• breathing problems,
• fever,
• joint pain,
• anemia,
• decrease white blood cell count,
• decrease platelets,
• allergic reactions, and
• others.

Quick GuideSymptoms of Mono: Infectious Mononucleosis Treatment

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.