gentamicin injection (Garamycin)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

Bacterial Infections 101 Pictures Slideshow

What is gentamicin-injection, and how does it work (mechanism of action)?

Gentamicin is a broad spectrum aminoglycoside antibiotic that is most effective against aerobic gram-negative rods. Gentamicin is also used in combination with other antibiotics to treat infections caused by gram positive organisms such as Staphylococcus aureus and certain species of streptococci. Additionally, gentamicin is used in combination with a penicillin antibiotic to treat endocarditis (infection of the heart). Gentamicin kills bacteria (bactericidal) by inhibiting the synthesis of bacterial proteins. Gentamicin irreversibly binds to the 30S ribosomal subunits. This binding interferes with the formation of messenger RNA (mRNA) and the subsequent formation of nonfunctional proteins and the eventual death of susceptible bacteria. Gentamicin was approved by the US Food and Drug Administration (FDA) in 1966.

What brand names are available for gentamicin-injection?

Gentamicin Injection, Garamycin

Is gentamicin-injection available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for gentamicin-injection?

Yes

What are the side effects of gentamicin-injection?

Side effects associated with gentamicin use are:

Quick GuideSymptoms of Mono: Infectious Mononucleosis Treatment

Symptoms of Mono: Infectious Mononucleosis Treatment

What is the dosage for gentamicin-injection?

The dose of gentamicin is usually based on body weight. Total daily dose and duration of treatment depend on the condition or infection being treated. Dose adjustment is necessary for patients who have impaired kidney function. Doses are adjusted to target peak and trough levels.

  • Usual dosage ranges for IM or IV:
  • Conventional dosing: Administer 1 to 2.5 mg/kg/dose every 8-12 hours.
  • Once daily dosing: Administer 4 to 7 mg/kg/day.

Which drugs or supplements interact with gentamicin-injection?

Gentamicin may decrease the effectiveness of the BCG and typhoid vaccine.

Cephalosporins, amphotericin B (Amphocin), cisplatin (Platinol), colistimethate, cyclosporine (Sandimmune), loop diuretics, mannitol (Osmitrol), and vancomycin (Vancocin) may increase the risk of experiencing kidney related side effects of gentamicin.

Nonsteroidal anti-inflammatory agents (NSAIDs) may decrease the kidney excretion or clearance of gentamicin. Examples of NSAIDs are:

Neuromuscular blocking agents may increase the risk of experiencing breathing problems by depressing the activity of respiratory muscles when given with gentamicin.

Loop diuretics such as furosemide (Lasix), bumetanide (Bumex), and torsemide (Demadex) may increase the ototoxicity (hearing impairment) associated with gentamicin treatment.

Is gentamicin-injection safe to take if I'm pregnant or breastfeeding?

Gentamicin is excreted into human milk. Due to the lack of safety data, gentamicin should be used cautiously in nursing mothers. The benefits of breastfeeding, potential risk of infant drug exposure, and risk of inadequately or untreated infection should all be considered when deciding if gentamicin should be used in females who are breastfeeding.

What else should I know about gentamicin-injection?

What preparations of gentamicin-injection are available?

Gentamicin sulfate solution for injection: 10, 40 mg/ml

How should I keep gentamicin-injection stored?

Gentamicin is usually given as an injection at the hospital, clinic, or doctor's office. Patient's using gentamicin solution at home should check with their healthcare provider on details regarding the proper storage of their medication.

REFERENCE: FDA Prescribing Information.

Last Editorial Review: 12/1/2014

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Reviewed on 12/1/2014
References
REFERENCE: FDA Prescribing Information.

Health Solutions From Our Sponsors