GENERIC NAME: gentamicin injection
BRAND NAME: Gentamicin Injection, Garamycin
DRUG CLASS AND MECHANISM: Gentamicin is a broad spectrum aminoglycoside antibiotic that is most effective against aerobic gram-negative rods. Gentamicin is also used in combination with other antibiotics to treat infections caused by gram positive organisms such as Staphylococcus aureus and certain species of streptococci. Additionally, gentamicin is used in combination with a penicillin antibiotic to treat endocarditis (infection of the heart). Gentamicin kills bacteria (bactericidal) by inhibiting the synthesis of bacterial proteins. Gentamicin irreversibly binds to the 30S ribosomal subunits. This binding interferes with the formation of messenger RNA (mRNA) and the subsequent formation of nonfunctional proteins and the eventual death of susceptible bacteria. Gentamicin was approved by the US Food and Drug Administration (FDA) in 1966.
GENERIC AVAILABLE: Yes
PRESCRIBED FOR: Gentamicin is used for the treatment of bacterial infections of the bone, respiratory tract, skin and soft tissue, stomach, urinary tract, blood, and heart. It is generally used to treat infections caused by gram negative bacterial species, including Pseudomonas, Proteus, Serratia, and gram positive Staphylococcus and certain species of streptococci.
SIDE EFFECTS: Side effects associated with gentamicin use are:
- high or low blood pressure,
- kidney problems,
- liver problems,
- injection site reactions,
- hair loss,
- electrolyte abnormalities,
- increased salivation,
- visual problems,
- hearing impairment,
- breathing problems,
- joint pain,
- decrease white blood cell count,
- decrease platelets,
- allergic reactions, and
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