Genetic Testing for Breast Cancer (cont.)
How Do I Interpret The Results?
A negative test means that a mutation was not identified. If genetic testing has previously identified a mutation in your family, then a negative test means you do not carry the specific mutation that was identified in your family. Therefore, you would have the same risk as the general population. If a BRCA1 or BRCA2 mutation has not been previously found in your family, a negative result should be interpreted cautiously. In such cases, there is still a chance you could develop breast cancer.
A positive test result means that a mutation known to increase the risk of breast and ovarian cancer was identified. Knowing your cancer risk may help guide important health care decisions for you and your family.
Should I Be Tested For Genetic Mutations?
You many want to discuss genetic testing with your doctor if any of the following scenarios apply to you:
- You have two or more blood relatives -- mother, sister, aunt, cousin or daughter -- with premenopausal breast cancer or ovarian cancer diagnosed at any age.
- You have been diagnosed with breast cancer, especially if it was diagnosed before you reached menopause and you have a blood relative with breast or ovarian cancer.
- You have been diagnosed with ovarian cancer and you have blood relatives who have had ovarian or breast cancer.
- You are related to someone (male or female) who has a BRCA1 or BRCA2 mutation.
- You are of Ashkenazi Jewish descent and you have blood relatives who have had breast or ovarian cancer, or you have had breast or ovarian cancer.
What Are My Options If I Have A "Cancer Gene?"
Women in high-risk categories (first-degree relative with breast cancer, personal history of breast cancer, prior abnormal breast biopsy results with atypical ductal hyperplasia or lobular carcinoma in situ) and carriers of the genes associated with breast cancer may want to consider starting regular breast cancer screening at age 30.
Some women choose preventive (prophylactic) mastectomy to decrease the chances of developing breast cancer, although this doesn't offer complete protection.
Another approach includes using the anti-estrogen drug tamoxifen (Nolvadex) or raloxifene, a drug used to treat osteoporosis, to help prevent development of the disease.
Next: What are the potential problems with genetic testing? »
- tamoxifen, Nolvadex -
- CA 125 - Read about CA 125, the blood test for ovarian cancer. This test however, will also be increased with benign conditions such as endometriosis, uterine fibroids, pelvic inflammatory disease, and others.
- Breast Cancer - Get the facts on breast cancer symptoms, signs, stages, types, research, risk factors, diagnosis, prevention information and treatment options: mastectomy, chemotherapy, radiation therapy.
Latest Medical News
Cancer RSS