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February 10, 2012

Genetic Testing for Breast Cancer Glossary of Terms

The following are health and medical definitions of terms that appear in the Genetic Testing for Breast Cancer article.

Abnormal: Not normal. Deviating from the usual structure, position, condition, or behavior. In referring to a growth, abnormal may mean that it is cancerous or premalignant (likely to become cancer).

Anxiety: A feeling of apprehension and fear characterized by physical symptoms such as palpitations, sweating, and feelings of stress. Anxiety disorders are serious medical illnesses that affect approximately 19 million American adults. These disorders fill people's lives with overwhelming anxiety and fear. Unlike the relatively mild, brief anxiety caused by a stressful event such as a business presentation or a first date, anxiety disorders are chronic, relentless, and can grow progressively worse if not treated.
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Atypical: Not typical, not usual, not normal, abnormal. Atypical is often used to refer to the appearance of precancerous or cancerous cells.

Biopsy: The removal of a sample of tissue for purposes of diagnosis. (Many definitions of "biopsy" stipulate that the sample of tissue is removed for examination under a microscope. This may or may not be the case. The diagnosis may be achieved by other means such as by analysis of chromosomes or genes.)
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BRCA2: A gene that normally acts to restrain the growth of cells in the breast and ovary but which, when mutated, may predispose to breast cancer and to ovarian cancer. BRCA2 mutations have also been discovered to be responsible for a significant fraction of early-onset prostate cancer. The first breast cancer genes identified were BRCA1 and BRCA2. Mutations of BRCA1 and BRCA2 account for about half of all cases of inherited breast cancer. These tumors tend to occur in young women. BRCA1 and BRCA2 are usually not involved in breast cancer that is not hereditary.
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Breast biopsy: A procedure in which a sample of a suspicious breast growth is removed and examined, usually for the presence of cancer. The sample is suctioned out through a needle or removed surgically.
See the entire definition of Breast biopsy

Breast cancer: Breast cancer is diagnosed with self- and physician-examination of the breasts, mammography, ultrasound testing, and biopsy. There are many types of breast cancer that differ in their capability of spreading to other body tissues (metastasis). Treatment of breast cancer depends on the type and location of the breast cancer, as well as the age and health of the patient. The American Cancer Society recommends that a woman should have a baseline mammogram between the ages of 35 and 40 years. Between 40 and 50 years of age mammograms are recommended every other year. After age 50 years, yearly mammograms are recommended.

Breast cancer gene: One of the genes that contributes to breast cancer. See also: BRCA breast cancer gene.

Cancer: An abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize (spread).
See the entire definition of Cancer

Carcinoma: Cancer that begins in the skin or in tissues that line or cover body organs. For example, carcinoma can arise in the breast, colon, liver, lung, prostate, and stomach.

Carcinoma in situ: Cancer that involves only the place in which it began and that has not spread. Carcinoma in situ is an early-stage tumor.
See the entire definition of Carcinoma in situ

Diagnosis: 1 The nature of a disease; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies. 3 The identification of any problem. The diagnosis was a plugged IV.
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Family history: The family structure and relationships within the family, including information about diseases in family members.
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Gene: The basic biological unit of heredity. A segment of deoxyribonucleic acid (DNA) needed to contribute to a function.
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Genes: The basic biological units of heredity. Segments of deoxyribonucleic acid (DNA) needed to contribute to a function.
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Genetic: Having to do with genes and genetic information.

Genetic counseling: An educational counseling process for individuals and families who have a genetic disease or who are at risk for such a disease. Genetic counseling is designed to provide patients and their families with information about their condition and help them make informed decisions.
See the entire definition of Genetic counseling

Genetic testing: Tests done for clinical genetic purposes. Genetic tests may be done for diverse purposes pertaining to clinical genetics, including the diagnosis of genetic disease in children and adults; the identification of future disease risks; the prediction of drug responses; and the detection of risks of disease to future children.

Health Insurance Portability & Accountability Act: See: HIPAA.

HIPAA: Acronym that stands for the Health Insurance Portability and Accountability Act, a US law designed to provide privacy standards to protect patients' medical records and other health information provided to health plans, doctors, hospitals and other health care providers. Developed by the Department of Health and Human Services, these new standards provide patients with access to their medical records and more control over how their personal health information is used and disclosed. They represent a uniform, federal floor of privacy protections for consumers across the country. State laws providing additional protections to consumers are not affected by this new rule. HIPAA took effect on April 14, 2003.

Hyperplasia: A condition in which there is an increase in the number of normal cells in a tissue or organ.

In situ: In the normal location. An "in situ" tumor is one that is confined to its site of origin and has not invaded neighboring tissue or gone elsewhere in the body.
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Mastectomy: A general term for removal of the breast, usually to remove cancerous tissue. The operation can be done in a hospital or in an outpatient clinic, depending on how extensive it needs to be. It takes from two to three hours, with three to five weeks for full recovery. Drainage shunts are left in the surgical incision for a few days after the operation; these are removed in three to five days if the area is healing normally. After the mastectomy, reconstructive surgery may be performed to restore a more normal appearance. Many patients choose to avoid reconstructive surgery, and wear special undergarments instead. In cases of non- metastatic breast cancer, a lumpectomy, radiation, chemotherapy, or a combination of these treatments may prove a viable alternative to mastectomy. If a lumpectomy is chosen, the surgeon may remove some lymph node tissue from under the arms to make sure cancer has not spread.
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Menopause: The time in a woman's life when menstrual periods permanently stop; it is also called the "change of life." Menopause is the opposite of the menarche.
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Mutation: A permanent change, a structural alteration, in the DNA or RNA. In humans and many other organisms, mutations occur in DNA. However, in retroviruses like HIV, mutations occur in RNA which is the genetic material of retroviruses.
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Osteoporosis: Thinning of the bones with reduction in bone mass due to depletion of calcium and bone protein. Osteoporosis predisposes a person to fractures, which are often slow to heal and heal poorly. It is more common in older adults, particularly post-menopausal women; in patients on steroids; and in those who take steroidal drugs. Unchecked osteoporosis can lead to changes in posture, physical abnormality (particularly the form of hunched back known colloquially as "dowager's hump"), and decreased mobility.
See the entire definition of Osteoporosis

Ovarian: Of or pertaining to the ovary.

Ovarian cancer: Cancer of the ovary, the egg sac of females. The anatomic location of the ovaries:


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Pedigree: In medicine, a family health history diagrammed with a set of international symbols to indicate the individuals in the family, their relationships to one another, those with a disease, etc.

Prophylactic: A preventive measure. The word comes from the Greek for "an advance guard," an apt term for a measure taken to fend off a disease or another unwanted consequence.
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Registry: Although a registry was originally the place (like Registry House in Edinburgh) where information was collected (in registers), the word registry has also come to mean the collection itself. A registry is usually organized so the data can be analyzed. For example, analysis of data in a tumor registry maintained at a hospital may show a rise in lung cancer among women.

Surgery: The word "surgery" has multiple meanings. It is the branch of medicine concerned with diseases and conditions which require or are amenable to operative procedures. Surgery is the work done by a surgeon. By analogy, the work of an editor wielding his pen as a scalpel is s form of surgery. A surgery in England (and some other countries) is a physician's or dentist's office.
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    • Breast Cancer
      • Breast cancer is the most common cancer in women and the second most common cause of cancer death in women in the U.S. Symptoms include a lump in the breast or underarm area, nipple pain, change in breast size or shape, an inverted nipple, nipple discharge, and breast skin changes. Treatment may involve chemotherapy, radiation therapy, biological therapy, hormone therapy, or surgery.
    • Breast
      • The breast generally refers to the chest, however, more specifically, to the mammary gland. The mammary gland is a milk producing gland comprised largely of fat. Within the mammary gland is a complex network of branching ducts. The ducts exit from sac-like structures called lobules, which can produce milk in females. The darkened area around the nipple is called the areola. Common medical concerns in regard to the breast include breast lumps, breast cysts, breast cancer, and breast infections.
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      • Women's health is an important topic area to guide a woman through the stages of her life, as well as knowing the conditions and diseases that may occur. Educating yourself so that the transitions into different phases of life is key to a healthy, happy, and productive life.
    • Breast Cancer Prevention
      • Lifestyle changes, a healthy antioxidant-rich diet, exercise, and weight reduction can help reduce a woman's risk of developing breast cancer. It's important to be aware of how risk factors such as family history, lifestyle factors, breast conditions, radiation therapy, and hormonal factors may influence your chances of developing breast cancer. Mammography and breast self-examinations are crucial steps in breast cancer prevention.
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    • Genetic Counseling
      • Your health care provider may refer you to a genetic professional. Universities and medical centers also often have affiliated genetic professionals, or can provide referrals to a genetic professional or genetics clinic. Genetic counseling provides patients and family members the tools to make the right choice in regard to test for a disease or condition.
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Genetic Testing for Breast Cancer

What is a breast biopsy?

A breast biopsy is a procedure in which part or all of a suspicious breast growth is removed and examined, usually for the presence of cancer. The growth sample is suctioned out through a needle or cut out using a surgical procedure. The sample is then examined and evaluated under a microscope by a pathologist to identify non-cancerous (benign) or cancerous (malignant) tissue.

Words used to refer to the abnormal area or growth before and after diagnosis may include lump, mass, lesion, and tumor.

What is the purpose of a breast biopsy?

The basic aim of a breast biopsy is to determine whether or not a worrisome lump is cancer and, if it is cancer, what type it is. When no cancer is detected, the diagnosis of a benign or harmless lump is reassuring.

What specialties of physicians and practitioners do breast biopsies?

Many physicians and healthcare practitioners can be invol...

Read the Breast Biopsy article »




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