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gemifloxacin-oral, Factive Glossary of Terms

The following are health and medical definitions of terms that appear in the gemifloxacin-oral, Factive article.

Abdominal: Relating to the abdomen, the belly , that part of the body that contains all of the structures between the chest and the pelvis . The abdomen is separated anatomically from the chest by the diaphragm , the powerful muscle spanning the body cavity below the lungs .
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Absorption: Uptake. In the biomedical sciences, absorption has diverse specific meanings.
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Allergic reaction: The hypersensitive response of the immune system of an allergic individual to a substance.
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Aluminum: A naturally occurring element that makes up about 8% of the surface of the earth and is always found combined with other elements such as oxygen, silicon, and fluorine. Aluminum is is the most common metallic element in the earth's crust but has no clear biologic role. Everyone is exposed to low levels of aluminum from food, air, and water. Exposure to high levels of aluminum may result in respiratory problems (aluminosis). Inhalation of bauxite (aluminum ore) fumes may cause pulmonary fibrosis . Aluminum in the bloodstream may lead to neurological symptoms and may be fatal.
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Amitriptyline: An antidepressant medication. In some patients with depression, abnormal levels of brain chemicals called neurotransmitters may relate to the depression. Amitriptyline elevates mood by raising the level of neurotransmitters in brain tissue. Amitriptyline is also a sedative that is useful for depressed patients with insomnia, restlessness, and nervousness. It is sometimes used to treat fibromyalgia and symptoms related to chronic pain. Brand names are Elavil and Endep. A generic version is available.

Antibiotic: A drug used to treat infections caused by bacteria and other microorganisms. Originally, an antibiotic was a substance produced by one microorganism that selectively inhibits the growth of another. Synthetic antibiotics, usually chemically related to natural antibiotics, have since been produced that accomplish comparable tasks.
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Arteriosclerosis: Hardening and thickening of the walls of the arteries. Arteriosclerosis can occur because of fatty deposits on the inner lining of arteries (atherosclerosis), calcification of the wall of the arteries, or thickening of the muscular wall of the arteries from chronically elevated blood pressure (hypertension).

Attention: The ability to focus selectively on a selected stimulus, sustaining that focus and shifting it at will. The ability to concentrate.
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Bacteria: Single-celled microorganisms which can exist either as independent (free-living) organisms or as parasites (dependent upon another organism for life).
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Bacterial: Of or pertaining to bacteria. For example, a bacterial lung infection.

Blood: The familiar red fluid in the body that contains white and red blood cells, platelets, proteins, and other elements. The blood is transported throughout the body by the circulatory system. Blood functions in two directions: arterial and venous. Arterial blood is the means by which oxygen and nutrients are transported to tissues while venous blood is the means by which carbon dioxide and metabolic by-products are transported to the lungs and kidneys, respectively, for removal from the body.

Blood count: The calculated number of white or red blood cells (WBCs or RBCs) in a cubic millimeter of blood.

Blood glucose: The main sugar that the body makes from the food in the diet. Glucose is carried through the bloodstream to provide energy to all cells in the body. Cells cannot use glucose without the help of insulin .
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Blood sugar: Blood glucose. See also: High blood sugar; Low blood sugar.

Brain: That part of the central nervous system that is located within the cranium ( skull ). The brain functions as the primary receiver, organizer and distributor of information for the body. It has two (right and left) halves called "hemispheres."
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Breast : The breast refers to the front of the chest or, more specifically, to the mammary gland. The mammary gland is a milk producing gland. It is composed largely of fat. Within the mammary gland is a complex network of branching ducts. These ducts exit from sac-like structures called lobules, which can produce milk in females. The ducts exit the breast at the nipple.
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Breathing: The process of respiration, during which air is inhaled into the lungs through the mouth or nose due to muscle contraction, and then exhaled due to muscle relaxation.

Cardiomyopathy: Disease of the heart muscle (the myocardium). From the Greek roots: "cardio-", heart + "mys", muscle + "pathos", disease = disease (of the) heart muscle.

Cerebral: Pertaining to the brain, the cerebrum or the intellect.
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Chest: The area of the body located between the neck and the abdomen . The chest contains the lungs , the heart and part of the aorta . The walls of the chest are supported by the dorsal vertebrae , the ribs , and the sternum .
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Chest pain: There are many causes of chest pain. One is angina which results from inadequate oxygen supply to the heart muscle. Angina can be caused by coronary artery disease or spasm of the coronary arteries. Chest pain can also be due to a heart attack (coronary occlusion) and other important diseases such as, for example, dissection of the aorta and a pulmonary embolism. Do not try to ignore chest pain and "work (or play) though it." Chest pain is a warning to seek medical attention.

Colitis: Inflammation of the large intestine (the colon). There are many forms of colitis, including ulcerative, Crohn's, infectious, pseudomembranous, and spastic. For example, intermittent rectal bleeding, crampy abdominal pain and diarrhea can be symptoms of ulcerative colitis. Diagnosis can be made by barium enema, but direct visualization (sigmoidoscopy or colonoscopy) is the most accurate test. Long-standing ulcerative colitis increases the risk for colon cancer. Ulcerative colitis can also be associated with inflammation in joints, spine, skin, eyes, the liver and its bile ducts. Treatment of ulcerative colitis can involve medications and surgery.

Common cold: A viral upper respiratory tract infection. This contagious illness can be caused by many different types of viruses , and the body can never build up resistance to all of them. For this reason, colds are a frequent and recurring problem. In fact kindergarten children average 12 colds per year, while adolescents and adults have around seven colds per year.
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Condition: The term "condition" has a number of biomedical meanings including the following:

  1. An unhealthy state, such as in "this is a progressive condition."
  2. A state of fitness, such as "getting into condition."
  3. Something that is essential to the occurrence of something else; essentially a "precondition."
  4. As a verb: to cause a change in something so that a response that was previously associated with a certain stimulus becomes associated with another stimulus; to condition a person, as in behavioral conditioning.

Constipation: Infrequent (and frequently incomplete) bowel movements. The opposite of diarrhea, constipation is commonly caused by irritable bowel syndrome, diverticulosis, and medications (constipation can paradoxically be caused by overuse of laxatives). Colon cancer can narrow the colon and thereby cause constipation. The large bowel (colon) can be visualized by barium enema x-rays, sigmoidoscopy, and colonoscopy. Barring a condition such as cancer, high-fiber diets can frequently relieve the constipation.

Depression : An illness that involves the body, mood, and thoughts, that affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. A depressive disorder is not the same as a passing blue mood. It is not a sign of personal weakness or a condition that can be wished away. People with a depressive disease cannot merely "pull themselves together" and get better. Without treatment, symptoms can last for weeks, months, or years. Appropriate treatment, however, can help most people with depression.
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Diabetes: Refers to diabetes mellitus or, less often, to diabetes insipidus . Diabetes mellitus and diabetes insipidus share the name "diabetes" because they are both conditions characterized by excessive urination (polyuria).
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Diarrhea : A familiar phenomenon with unusually frequent or unusually liquid bowel movements, excessive watery evacuations of fecal material. The opposite of constipation . The word "diarrhea" with its odd spelling is a near steal from the Greek "diarrhoia" meaning "a flowing through." Plato and Aristotle may have had diarrhoia while today we have diarrhea. There are myriad infectious and noninfectious causes of diarrhea.
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Discharge: 1.The flow of fluid from part of the body, such as from the nose or vagina.
2. The passing of an action potential, such as through a nerve or muscle fiber .
3. The release of a patient from a course of care. The doctor may then dictate a discharge summary.
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Disease: Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the rubella (German measles) virus.

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Dizziness : Painless head discomfort with many possible causes including disturbances of vision, the brain, balance (vestibular) system of the inner ear, and gastrointestinal system. Dizziness is a medically indistinct term which laypersons use to describe a variety of conditions ranging from lightheadedness, unsteadiness to vertigo.
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Dry mouth: The condition of not having enough saliva to keep the mouth wet. This is due to inadequate function of the salivary glands. Everyone has dry mouth once in a while when they are nervous, upset or under stress. But if someone has a dry mouth most all of the time, it can be uncomfortable and lead to serious health problems.
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Fatigue: A condition characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness and tiredness. Fatigue can be acute and come on suddenly or chronic and persist.
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Fever : Although a fever technically is any body temperature above the normal of 98.6 degrees F. (37 degrees C.), in practice a person is usually not considered to have a significant fever until the temperature is above 100.4 degrees F (38 degrees C.).
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Flu: Short for influenza. The flu is caused by viruses that infect the respiratory tract which are divided into three types, designated A, B, and C. Most people who get the flu recover completely in 1 to 2 weeks, but some people develop serious and potentially life-threatening medical complications, such as pneumonia. Much of the illness and death caused by influenza can be prevented by annual influenza vaccination.

Fungal: Pertaining to a fungus. For example, a fungal skin infection.

Generic: 1. The chemical name of a drug. 2. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug may be sold. 3.A term referring to any drug marketed under its chemical name without advertising.

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Glucose: The simple sugar (monosaccharide) that serves as the chief source of energy in the body. Glucose is the principal sugar the body makes. The body makes glucose from proteins, fats and, in largest part, carbohydrates. Glucose is carried to each cell through the bloodstream. Cells, however, cannot use glucose without the help of insulin . Glucose is also known as dextrose.
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Headache : A pain in the head with the pain being above the eyes or the ears, behind the head (occipital), or in the back of the upper neck. Headache, like chest pain or back ache, has many causes.
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Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest.
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Heart rate: The number of heart beats per unit time, usually per minute. The heart rate is based on the number of contractions of the ventricles (the lower chambers of the heart). The heart rate may be too fast ( tachycardia ) or too slow ( bradycardia ). The pulse is bulge of an artery from the wave of blood coursing through the blood vessel as a result of the heart beat. The pulse is often taken at the wrist to estimate the heart rate.
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High blood sugar: An elevated level of the sugar glucose in the blood. Also called hyperglycemia .
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Hives: A raised, itchy area of skin that is usually a sign of an allergic reaction. It can be rounded or flat-topped but is always elevated above the surrounding skin. It reflects circumscribed dermal edema (local swelling of the skin). The hives are usually well circumscribed but may be coalescent and will blanch with pressure. They typically last less than 4 hours but they may stay for days or weeks. Approximately 20% of the population has experienced a bout of hives.
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Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
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Insulin: A natural hormone made by the pancreas that controls the level of the sugar glucose in the blood. Insulin permits cells to use glucose for energy. Cells cannot utilize glucose without insulin.
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Intracranial: Within the cranium , the bony dome that houses and protects the brain.
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Iron: An essential mineral. Iron is necessary for the transport of oxygen (via hemoglobin in red blood cells) and for oxidation by cells (via cytochrome). Deficiency of iron is a common cause of anemia. Food sources of iron include meat, poultry, eggs, vegetables and cereals (especially those fortified with iron). According to the National Academy of Sciences, the Recommended Dietary Allowances of iron are 15 milligrams per day for women and 10 milligrams per day for men. Iron overload can damage the heart, liver, gonads and other organs. Iron overload is a particular risk in people who may have certain genetic conditions (hemochromatosis) sometimes without knowing it and also in people receiving recurrent blood transfusions. Iron supplements meant for adults (such as pregnant women) are a major cause of poisoning in children.

Itching: An uncomfortable sensation in the skin that feels as if something is crawling on the skin or in the skin, and makes the person want to scratch the affected area.
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Kidney: One of a pair of organs located in the right and left side of the abdomen which clear "poisons" from the blood, regulate acid concentration and maintain water balance in the body by excreting urine. The kidneys are part of the urinary tract. The urine then passes through connecting tubes called "ureters" into the bladder. The bladder stores the urine until it is released during urination.


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Laboratory: A place for doing tests and research procedures and preparing chemicals, etc. Although "laboratory" looks very like the Latin "laboratorium" (a place to labor, a work place), the word "laboratory" came from the Latin "elaborare" (to work out, as a problem, and with great pains), as evidenced by the Old English spelling "elaboratory" designating "a place where learned effort was applied to the solution of scientific problems."
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Liver: An organ in the upper abdomen that aids in digestion and removes waste products and worn-out cells from the blood. The liver is the largest solid organ in the body. The liver weighs about three and a half pounds (1.6 kilograms). It measures about 8 inches (20 cm) horizontally (across) and 6.5 inches (17 cm) vertically (down) and is 4.5 inches (12 cm) thick.


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Liver disease: Liver disease refers to any disorder of the liver. The liver is a large organ in the upper right abdomen that aids in digestion and removes waste products from the blood.
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Low blood sugar: A low blood level of the sugar glucose. Also called hypoglycemia .
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Magnesium: A mineral involved in many processes in the body including nerve signaling, the building of healthy bones, and normal muscle contraction . About 350 enzymes are known to depend on magnesium.
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Medical history: 1. In clinical medicine, the patient's past and present which may contain clues bearing on their health past, present, and future. The medical history, being an account of all medical events and problems a person has experienced, including psychiatric illness, is especially helpful when a differential diagnosis is needed.
2. The history of medicine.

Medication: 1. A drug or medicine. 2. The administration of a drug or medicine. (Note that "medication" does not have the dangerous double meaning of "drug.")

Mouth: 1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral.

Narcotic: 1. A drug that causes insensibility or stupor. A narcotic induces narcosis, from the Greek "narke" for "numbness or torpor."
2. A drug such as marijuana which is subject to regulatory restrictions comparable to those for addictive narcotics.

Nausea: Nausea is the urge to vomit. It can be brought by many causes including, systemic illnesses, such as influenza, medications, pain, and inner ear disease. When nausea and/or vomiting are persistent, or when they are accompanied by other severe symptoms such as abdominal pain, jaundice, fever, or bleading, a physican should be consulted.

Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia . Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
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Pediatric: Pertaining to children.

Pharmacist: A professional who fills prescriptions, and in the case of a compounding pharmacist, makes them. Pharmacists are familiar with medication ingredients, interactions, cautions, and hints.
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Poison: Any substance that can cause severe distress or death if ingested, breathed in, or absorbed through the skin. Many substances that normally cause no problems, including water and most vitamins, can be poisonous if taken in too large of a quantity. Poison treatment depends on the substance: if there are treatment instructions on the substance's container and you are sure it contained no other item, follow those directions immediately. Always contact your nearest Poison Control Center if you are concerned about possible poison ingestion.

Poison Control Center: Special information centers set up to inform Americans about how to respond to potential poisoning. These centers maintain a database of poisons and appropriate emergency treatment. The Poison Control Center in your area should be listed with other community service numbers in the front of your telephone book, and can also be reached immediately through any telephone operator.
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Potassium: The major positive ion (cation) found inside of cells. The chemical notation for potassium is K+.
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Pregnancy: The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long.
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Prescription: A physician's order for the preparation and administration of a drug or device for a patient. A prescription has several parts. They include the superscription or heading with the symbol "R" or "Rx", which stands for the word recipe (meaning, in Latin, to take); the inscription, which contains the names and quantities of the ingredients; the subscription or directions for compounding the drug; and the signature which is often preceded by the sign "s" standing for signa (Latin for mark), giving the directions to be marked on the container.

Pseudomembranous colitis: Severe inflammation of the inner lining of the colon. Pseudomembranous colitis is characterized by pus and blood in the stool and often caused by antibiotics.

Pulse: The rhythmic contraction and expansion of an artery due to the surge of blood from the beat of the heart. The pulse is most often measured by feeling the arteries of the wrist. There is also a pulse, although far weaker, in veins.

Rash : Breaking out (eruption) of the skin. Medically, a rash is referred to as an exanthem.
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Relapse: The return of signs and symptoms of a disease after a patient has enjoyed a remission . For example, after treatment a patient with cancer of the colon went into remission with no sign or symptom of the tumor, remained in remission for 4 years, but then suffered a relapse and had to be treated once again for colon cancer.
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Rupture: A break or tear in any organ (such as the spleen) or soft tissue (such as the achilles tendon). Rupture of the appendix is more likely among uninsured and minority children when they develop appendicitis.

Section: 1) In anatomy, a slice of tissue. A biopsy obtained by surgery is usually sectioned (sliced), and these sections are inspected under a microscope. 2) In obstetrics, short for Caesarian section. 3) In surgery, the division of tissue during an operation.

Seizure: Uncontrolled electrical activity in the brain, which may produce a physical convulsion, minor physical signs, thought disturbances, or a combination of symptoms.
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Sensitivity: 1. In psychology, the quality of being sensitive. As, for example, sensitivity training, training in small groups to develop a sensitive awareness and understanding of oneself and of ones relationships with others. 2. In disease epidemiology, the ability of a system to detect epidemics and other changes in disease occurrence. 3. In screening for a disease, the proportion of persons with the disease who are correctly identified by a screening test. 4. In the definition of a disease, the proportion of persons with the disease who are correctly identified by defined criteria.

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Side effects: Problems that occur when treatment goes beyond the desired effect. Or problems that occur in addition to the desired therapeutic effect.
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Skin: The skin is the body's outer covering. It protects us against heat and light, injury, and infection. It regulates body temperature and stores water, fat, and vitamin D. Weighing about 6 pounds, the skin is the body's largest organ. It is made up of two main layers; the outer epidermis and the inner dermis.


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Sore: 1. (adjective) A popular term for painful. I have sore fingers from typing dictionary terms. She has a sore throat . 2. (noun) A nondescript term for nearly any lesion of the skin or mucous membranes. He has a number of sores in his mouth.

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Sore throat : Pain in the throat. Sore throat may be caused by many different causes, including inflammation of the larynx, pharynx, or tonsils.
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Stomach: 1. The sac-shaped digestive organ that is located in the upper abdomen, under the ribs. The upper part of the stomach connects to the esophagus, and the lower part leads into the small intestine.
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Stool: The solid matter discharged in a bowel movement.

Suicidal: Pertaining to suicide. the taking of ones own life. As in a suicidal gesture, suicidal thought, or suicidal act. An "online lifeline for suicidal undergrads" may help prevent college students from committing suicide.

Sunburn: Sunburn is an inflammation of the skin that develops in response to exposure to ultraviolet (UV) radiation from the sun or from tanning beds and booths that emit UV radiation . Sunburn is manifested by reddened, painful skin that may develop blisters.
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Sunscreen: A substance that blocks the effect of the sun's harmful rays. Using lotions that contain sunscreens can reduce the risk of skin cancer, including melanoma.

Sweating: The act of secreting fluid from the skin by the sweat (sudoriferous) glands. These are small tubular glands situated within and under the skin (in the subcutaneous tissue). They discharge by tiny openings in the surface of the skin.
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Taste: Taste belongs to our chemical sensing system, or the chemosenses. The complicated process of tasting begins when molecules released by the substances stimulate special cells in the mouth or throat. These special sensory cells transmit messages through nerves to the brain where specific tastes are identified.
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Temperature: The temperature is the specific degree of hotness or coldness of the body. It is usually measured with a thermometer.
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Tendon: The tissue by which a muscle attaches to bone. A tendon is somewhat flexible, but fibrous and tough. When a tendon becomes inflamed, the condition is referred to as tendinitis or tendonitis. Inflamed tendons are at risk for rupture.
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Therapy: The treatment of disease .
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Throat: The throat is the anterior (front) portion of the neck beginning at the back of the mouth , consisting anatomically of the pharynx and larynx . The throat contains the trachea and a portion of the esophagus .
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Thrush: Yeast infection of the mouth and throat, characterized by patches of white, caused by the fungus Candida albicans .
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Urine: Liquid waste. The urine is a clear, transparent fluid. It normally has an amber color. The average amount of urine excreted in 24 hours is from 40 to 60 ounces (about 1,200 cubic centimeters). Chemically, the urine is mainly an aqueous (watery) solution of salt (sodium chloride) and substances called urea and uric acid. Normally, it contains about 960 parts of water to 40 parts of solid matter. Abnormally, it may contain sugar (in diabetes), albumen (a protein) (as in some forms of kidney disease), bile pigments (as in jaundice), or abnormal quantities of one or another of its normal components.

Vaccines: Microbial preparations of killed or modified microorganisms that can stimulate an immune response in the body to prevent future infection with similar microorganisms. These preparations are usually delivered by injection.
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Vaginal discharge: Vaginal discharge is a fluid produced by glands in the vaginal wall and cervix that drains from the opening of the vagina . The amount and appearance of normal vaginal discharge varies throughout the menstrual cycle . An increase in the amount of vaginal discharge, an abnormal odor or consistency of the fluid, or pain that accompanies vaginal discharge can all be signs of infection or other disorders. Such disorders include (this is not an all inclusive list) bacterial vaginosis , yeast vaginitis , and vaginitis .
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Vaginal yeast infection: Infection of the vagina caused by a fungus known as Candida. A yeast vaginal infection is characterized by itching, burning, soreness, pain during intercourse and/or urination, and vaginal discharge that is typically cheesy white in color. The diagnosis is confirmed through identification of the yeast under a microscope from a specimen scraped from the vaginal area. A yeast vaginal infection that is causing symptoms is treated with topical medications applied in and around the vagina and with medications taken by mouth. Topical antibiotic creams include butoconazole (Femstat 3), clotrimazole (Lotrimin), miconazole (Monistat), and terconazole (Terazol 3). Clotrimazole, miconazole, terconazole, and nystatin (Mycostatin) are also available as vaginal tablets. Oral antibiotics for yeast vaginitis include fluconazole (Diflucan). During pregnancy, only the topical creams are used.
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Viral: Of or pertaining to a virus. For example, "My daughter has a viral rash ."
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Warfarin : An anticoagulant drug (brand names: Coumarin, Panwarfin, Sofarin) taken to prevent the blood from clotting and to treat blood clots and overly thick blood. Warfarin is also used to reduce the risk of clots causing strokes or heart attacks .
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Yeast: A group of single-celled fungi that reproduce by budding.
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Yeast infection: Overgrowth of yeast can affect the skin (yeast rash ), mouth (thrush), digestive tract, esophagus, vagina ( vaginitis ), and other parts of the body. Yeast infections occur most frequently in moist areas of the body. Although Candida albicans and other Candida yeasts are the most frequent offenders, other yeast groups are known to cause illness, primarily in immunocompromised patients. These include Torulopsis, Cryptococcus, Malassezia, and Trichosporon yeasts. Diagnosis is by observation, and can be confirmed by culturing a stool or mucosa sample, or a scraping from the affected area. Treatment is by topical or oral antifungal medications. Acidophilous, a helpful bacteria that normally helps to keep yeast in check, can also be tried in supplement form or in yogurt with live cultures.
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Zinc: A mineral essential to the body, zinc is a constituent of many enzymes that permit chemical reactions to proceed at normal rates. It is involved in the manufacture of protein (protein synthesis) and in cell division. Zinc is also a constituent of insulin , and is concerned with the sense of smell.
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