gemfibrozil, Lopid (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Gemfibrozil can increase the effect of the blood thinner, warfarin (Coumadin), and thus may lead to bleeding. Therefore, patients on warfarin may need to have their doses of warfarin reduced when starting gemfibrozil.
Colestipol (Colestid) and cholestyramine (Questran) reduce the absorption of gemfibrozil and reduce its effectiveness if taken at the same time. Therefore, gemfibrozil should be administered one hour before or 4-6 hours after administering colestipol or cholestyramine.
PREGNANCY: The effect of gemfibrozil in pregnant women has not been well-studied. Gemfibrozil should be used during pregnancy only if the potential benefit justifies the unknown but potential risk to the fetus.
NURSING MOTHERS: It is not known whether gemfibrozil is excreted in human milk.
SIDE EFFECTS: Common side effects of gemfibrozil include upset stomach, stomach pain, diarrhea, headache, tiredness, nausea, and vomiting. Muscle aches and pain also occur. Rarely, these muscle-related symptoms are associated with damage to muscles that releases chemicals into the blood that that can damage the kidney. Muscle damage is of greatest concern when gemfibrozil is combined with statins. The formation of gallstones and gallbladder surgery have been associated with the use of gemfibrozil. Pancreatitis, abnormal blood liver tests, as well as reduced red blood cells (anemia), white blood cells (leukopenia) and blood platelets (thrombocytopenia) also have been reported.
Reference: FDA Prescribing Information
Medically Reviewed by a Doctor on 10/29/2014
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