- What is gefitinib, and how does it work (mechanism of action)?
- What brand names are available for gefitinib?
- Is gefitinib available as a generic drug?
- Do I need a prescription for gefitinib?
- What are the side effects of gefitinib?
- What is the dosage for gefitinib?
- Which drugs or supplements interact with gefitinib?
- Is gefitinib safe to take if I'm pregnant or breastfeeding?
- What else should I know about gefitinib?
What is gefitinib, and how does it work (mechanism of action)?
Gefitinib is a drug that is used to treat several types of lung cancer. It works by preventing lung cancer cells from growing and multiplying. Many cells, including cancer cells, have receptors on their surfaces for epidermal growth factor (EGF), a protein that is normally produced by the body and that promotes the growth and multiplication of cells. When EGF attaches to epidermal growth factor receptors (EGFRs), it causes an enzyme called tyrosine kinase to become active within the cells. Tyrosine kinase triggers chemical processes that cause the cells, including cancer cells, to grow, multiply, and spread. Gefitinib attaches to EGFRs and thereby blocks the attachment of EGF and the activation of tyrosine kinase. This mechanism for stopping cancer cells from growing and multiplying is very different from the mechanisms of chemotherapy and hormonal therapy. Gefitinib was approved by the FDA in May 2003.
What brand names are available for gefitinib?
Is gefitinib available as a generic drug?
GENERIC AVAILABLE: No.
Do I need a prescription for gefitinib?
What are the side effects of gefitinib?
About one in one hundred persons receiving gefitinib develop a potentially serious lung condition called interstitial lung disease that causes inflammation within the lung. Therefore, patients taking gefitinib who develop new or worsening cough, fever, or difficulty in breathing should contact their physician immediately.
Eye irritation has been observed in patients receiving gefitinib, and patients who develop the onset of new eye symptoms should contact their physician.
All patients taking gefitinib should seek medical advice promptly if they develop severe or persistent
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