DRUG INTERACTIONS: See also How to Use section. Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first. This drug should not be used with the following medications because very serious interactions may occur: certain antiarrhythmics (e.g., quinidine, procainamide, amiodarone, dofetilide, sotalol). If you are currently using any of these medications, tell your doctor or pharmacist before starting gatifloxacin. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: corticosteroids (e.g., prednisone, hydrocortisone), medications for diabetes (e.g., glyburide, glipizide), digoxin, non-steroidal anti-inflammatory drugs - NSAIDs (e.g., ibuprofen, naproxen), probenecid, live vaccines, drugs that lower potassium levels (e.g., diuretics such as furosemide, hydrochlorothiazide), warfarin. Other drugs besides gatifloxacin which may affect the heart rhythm (QTc prolongation in the EKG) include cisapride, certain macrolide antibiotics (e.g., erythromycin, clarithromycin), certain antipsychotic medications (e.g., pimozide, thioridazine, ziprasidone) among others. QTc prolongation can infrequently result in serious, rarely fatal, irregular heartbeats. Consult your doctor or pharmacist for more details, and for instructions on how you may minimize the risk of this effect. Also report the use of drugs which might increase seizure risk (decrease seizure threshold) when combined with gatifloxacin, such as tricyclic antidepressants (e.g., amitriptyline), isoniazid (INH), and theophylline among others. Consult your doctor or pharmacist for details.
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