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gatifloxacin-oral, Tequin (cont.)

PRECAUTIONS: Before taking gatifloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolones such as ciprofloxacin, levofloxacin, or moxifloxacin; or if you have any other allergies. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain heart rhythm disorders (QTc prolongation), low blood potassium levels. Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (e.g., cerebral atherosclerosis, tumors or increased intracranial pressure), diabetes, certain heart problems (e.g., bradycardia, myocardial infarction), kidney disease, mineral imbalance (e.g., low blood magnesium levels), muscle/joint/tendon problems, seizures, family history of certain heart rhythm disorders (QTc prolongation). This drug may make you dizzy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths or sunlamps. Use a sunscreen and wear protective clothing when outdoors. Caution is advised when using this drug in the elderly because they may be more sensitive to its side effects (e.g., blood sugar or tendon problems), especially if they are also taking corticosteroids (e.g., prednisone, hydrocortisone). Caution is advised when using this drug in children because they may be more sensitive to its possible side effects (e.g., joint/tendon problems). Discuss the risks and benefits with the doctor. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Based on information from related drugs, gatifloxacin may pass into breast milk. Breast-feeding while using this medication is not recommended. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: See also How to Use section. Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first. This drug should not be used with the following medications because very serious interactions may occur: certain antiarrhythmics (e.g., quinidine, procainamide, amiodarone, dofetilide, sotalol). If you are currently using any of these medications, tell your doctor or pharmacist before starting gatifloxacin. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: corticosteroids (e.g., prednisone, hydrocortisone), medications for diabetes (e.g., glyburide, glipizide), digoxin, non-steroidal anti-inflammatory drugs - NSAIDs (e.g., ibuprofen, naproxen), probenecid, live vaccines, drugs that lower potassium levels (e.g., diuretics such as furosemide, hydrochlorothiazide), warfarin. Other drugs besides gatifloxacin which may affect the heart rhythm (QTc prolongation in the EKG) include cisapride, certain macrolide antibiotics (e.g., erythromycin, clarithromycin), certain antipsychotic medications (e.g., pimozide, thioridazine, ziprasidone) among others. QTc prolongation can infrequently result in serious, rarely fatal, irregular heartbeats. Consult your doctor or pharmacist for more details, and for instructions on how you may minimize the risk of this effect. Also report the use of drugs which might increase seizure risk (decrease seizure threshold) when combined with gatifloxacin, such as tricyclic antidepressants (e.g., amitriptyline), isoniazid (INH), and theophylline among others. Consult your doctor or pharmacist for details.



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