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 Gangrene Main Article |  Glossary |  Gangrene Index 

Gangrene Glossary of Terms

The following are health and medical definitions of terms that appear in the Gangrene article.

Abdomen: The belly , that part of the body that contains all of the structures between the chest and the pelvis . The abdomen is separated anatomically from the chest by the diaphragm , the powerful muscle spanning the body cavity below the lungs .
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Addiction: A chronic relapsing condition characterized by compulsive drug-seeking and abuse and by long-lasting chemical changes in the brain. Addiction is the same irrespective of whether the drug is alcohol, amphetamines, cocaine, heroin, marijuana, or nicotine. Every addictive substance induces pleasant states or relieves distress. Continued use of the addictive substance induces adaptive changes in the brain that lead to tolerance, physical dependence, uncontrollable craving and, all too often, relapse. Dependence is at such a point that stopping is very difficult and causes severe physical and mental reactions from withdrawal. The risk of addiction is in part inherited. Genetic factors, for example, account for about 40% of the risk of alcoholism. The genetic factors predisposing to addiction are not yet fully understood.

Adjacent: Lying nearby. Related terms include superjacent, subjacent, and circumjacent. From ad-, near + the Latin jacere, to lie = to lie near.

Amputation: Removal of part or all of a body part enclosed by skin. For example, removal of part of a finger or an entire finger would be termed an amputation. Removal of an appendix, on the other hand, would not be termed amputation. A person who has undergone an amputation is called an amputee.
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Anaerobic: Not requiring oxygen. Anaerobic bacteria do not need oxygen to grow; in fact, oxygen is usually toxic to them. An anaerobic environment lacks oxygen.

Angiogram: An x-ray of blood vessels which can be seen because the patient receives an injection of dye to outline the vessels on the x-ray.

Angiography: A procedure performed to view blood vessels after injecting them with a radioopaque dye that outlines them on x-ray. This technique can be usefully used to look at arteries in many areas of the body, including the brain, neck (carotids), heart, aorta, chest, pulmonary circuit, kidneys, gastrointestinal tract, and limbs.

Antibiotic: A drug used to treat infections caused by bacteria and other microorganisms. Originally, an antibiotic was a substance produced by one microorganism that selectively inhibits the growth of another. Synthetic antibiotics, usually chemically related to natural antibiotics, have since been produced that accomplish comparable tasks.
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Appendix: A small outpouching from the beginning of the large intestine (the ascending colon ). Formally called the vermiform appendix because it was thought to be wormlike.
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Arms: An appendage in anatomy and in clinical trials. See: Arm.

Arteriogram: An x-ray of blood vessels, which becomes visible after an injection of contrast solution into the circulation that appears on the x-ray film.

Arteriosclerosis: Hardening and thickening of the walls of the arteries. Arteriosclerosis can occur because of fatty deposits on the inner lining of arteries (atherosclerosis), calcification of the wall of the arteries, or thickening of the muscular wall of the arteries from chronically elevated blood pressure (hypertension).

Artery: A vessel that carries blood high in oxygen content away from the heart to the farthest reaches of the body. Since blood in arteries is usually full of oxygen, the hemoglobin in the red blood cells is oxygenated. The resultant form of hemoglobin (oxyhemoglobin) is what makes arterial blood look bright red.
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Atrophy: Wasting away or diminution. Muscle atrophy is wasting of muscle, decrease in muscle mass.
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Autoimmune: Pertaining to autoimmunity, a misdirected immune response that occurs when the immune system goes awry and attacks the body itself.
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Bacteria: Single-celled microorganisms which can exist either as independent (free-living) organisms or as parasites (dependent upon another organism for life).
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Bacterial: Of or pertaining to bacteria. For example, a bacterial lung infection.

Bacterium: The singular of bacteria.

Blood clot: Blood that has been converted from a liquid to a solid state. Also called a thrombus .
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Blood pressure: The blood pressure is the pressure of the blood within the arteries. It is produced primarily by the contraction of the heart muscle. It's measurement is recorded by two numbers. The first (systolic pressure) is measured after the heart contracts and is highest. The second (diastolic pressure) is measured before the heart contracts and lowest. A blood pressure cuff is used to measure the pressure. Elevation of blood pressure is called "hypertension".

Bowel: Another name for the intestine . The small bowel and the large bowel are the small intestine and large intestine , respectively.
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Cascade: A sequence of successive activation reactions involving enzymes (enzyme cascade) or hormones (hormone cascade) characterized by a series of amplifications of an initial stimulus. In blood coagulation, for example, each enzyme activates the next until the final product, the fibrin clot, is reached.

Chronic: This important term in medicine comes from the Greek chronos, time and means lasting a long time.
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Clostridium: A group of anaerobic bacteria (bacteria that thrive in the absence of oxygen ). There are 100+ species of Clostridium. They include, for examples, Clostridium difficile , Clostridium perfringens (also called Clostridium welchii), and Clostridium botulinum.
See the entire definition of Clostridium

Clostridium perfringens: A type of bacteria that is the most common agent of gas gangrene and can also cause food poisoning as well as a fulminant form of bowel disease called necrotizing colitis.
See the entire definition of Clostridium perfringens

Compression: 1. The act of pressing together. As in a compression fracture, nerve compression, or spinal cord compression.
2. To shorten in time. In embryology, there may be compression of development with some stages even omitted.

Connective tissue: A material made up of fibers forming a framework and support structure for body tissues and organs. Connective tissue surrounds many organs. Cartilage and bone are specialized forms of connective tissue. All connective tissue is derived from mesoderm, the middle germ cell layer in the embryo.

Contrast: Short for "contrast media." Contrast media are X-ray dyes used to provide contrast, for example, between blood vessels and other tissue.

Cuts: Severed skin. Washing a cut or scrape with soap and water and keeping it clean and dry is all that is required to care for most wounds. Putting alcohol hydrogen peroxide, and iodine into a wound can delay healing and should be avoided. Seek medical care early if you think that you might need stitches. Any delay can increase the rate of wound infection. Any puncture wound through tennis shoes has a high risk of infection and should be seen by your healthcare professional. Any redness, swelling, increased pain, or pus draining from the wound may indicate an infection that requires professional care.

Debridement: The act of debriding (removing dead, contaminated or adherent tissue or foreign material). Debridement encompasses enzymatic debridement (as with proteolytic enzymes), mechanical nonselective debridement (as in a whirlpool), and sharp debridement (by surgery). See: Debride.

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Diabetes: Refers to diabetes mellitus or, less often, to diabetes insipidus . Diabetes mellitus and diabetes insipidus share the name "diabetes" because they are both conditions characterized by excessive urination (polyuria).
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Diabetic neuropathy : A family of nerve disorders caused by diabetes . Diabetic neuropathies cause numbness and sometimes pain and weakness in the hands, arms, feet, and legs. Neurologic problems in diabetes may occur in every organ system, including the digestive tract, heart, and genitalia. People with diabetes can develop nerve problems at any time, but the longer a person has diabetes, the greater is the risk.
See the entire definition of Diabetic neuropathy

Diagnosis: 1 The nature of a disease ; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies . 3 The identification of any problem. The diagnosis was a plugged IV.
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Extremity: The extremities in medical language are not freezing cold or scorching heat but rather the uttermost parts of the body. The extremities are simply the hands and feet.
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Fasciitis : Inflammation of the fascia (a lining tissue under the skin that covers a surface of underlying tissues).
See the entire definition of Fasciitis

Fever : Although a fever technically is any body temperature above the normal of 98.6 degrees F. (37 degrees C.), in practice a person is usually not considered to have a significant fever until the temperature is above 100.4 degrees F (38 degrees C.).
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Fiber : The parts of plants that cannot be digested, namely complex carbohydrates. Also known as bulk or roughage.
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Fournier's gangrene : A horrendous infection of the genitalia that causes severe pain in the genital area (in the penis and scrotum or perineum ) and progresses from erythema (redness) to necrosis (death) of tissue . Gangrene can occur within hours. The mortality (death) rates are up to 50%.
See the entire definition of Fournier's gangrene

Frostbite: Damage to tissues from freezing due to the formation of ice crystals within cells, rupturing the cells and leading to cell death.
See the entire definition of Frostbite

Gallbladder: A pear-shaped organ just below the liver that stores the bile secreted by the liver. During a fatty meal, the gallbladder contracts, delivering the bile through the bile ducts into the intestines to help with digestion. Abnormal composition of bile leads to formation of gallstones, a process termed cholelithiasis. The gallstones cause cholecystitis, inflammation of the gallbladder.

Gangrene: The death of body tissue due to the loss of blood supply to that tissue, sometimes permitting bacteria to invade it and accelerate its decay.
See the entire definition of Gangrene

Genitalia: The male and female reproductive organs. The genitalia include internal structures such as the ovary, and external structures such as the penis. See also: Female organs of reproduction; Male organs of reproduction.

Glucose: The simple sugar (monosaccharide) that serves as the chief source of energy in the body. Glucose is the principal sugar the body makes. The body makes glucose from proteins, fats and, in largest part, carbohydrates. Glucose is carried to each cell through the bloodstream. Cells, however, cannot use glucose without the help of insulin . Glucose is also known as dextrose.
See the entire definition of Glucose

Hansen's disease: See: Hansen disease.

Hernia: A general term referring to a protrusion of a tissue through the wall of the cavity in which it is normally contained.
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Hyperbaric: Pertaining to gas pressures greater than 1 atmosphere* of pressure. Also pertaining to solutions that are more dense than the medium to which they are added. The term "hyperbaric" is derived from Greek roots: " hyper- " meaning high, beyond, excessive, above normal + "baros" meaning weight.
See the entire definition of Hyperbaric

Hypotension: Any blood pressure that is below the normal expected for an individual in a given environment. Hypotension is the opposite of hypertension (abnormally high blood pressure).
See the entire definition of Hypotension

Immune: Protected against infection. The Latin immunis means free, exempt.

Immune system: A complex system that is responsible for distinguishing us from everything foreign to us, and for protecting us against infections and foreign substances. The immune system works to seek and kill invaders.
See the entire definition of Immune system

Indicate: In medicine, to make a treatment or procedure advisable because of a particular condition or circumstance. For example, certain medications are indicated for the treatment of hypertension during pregnancy while others are contraindicated.

Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
See the entire definition of Infection

Injury: Harm or hurt. The term "injury" may be applied in medicine to damage inflicted upon oneself as in a hamstring injury or by an external agent on as in a cold injury. The injury may be accidental or deliberate, as with a needlestick injury. The term "injury" may be synonymous (depending on the context) with a wound or with trauma.

Leprosy: See: Hansen disease.

Limb: The arm or leg.

Low blood pressure : Any blood pressure that is below the normal expected for an individual in a given environment. Low blood pressure is also referred to as hypotension.
See the entire definition of Low blood pressure

Male genitalia: The genital organs of the male. These are usually separated by convention into the external and internal genitalia.
See the entire definition of Male genitalia

Mortality: A fatal outcome or, in one word, death. The word "mortality" is derived from "mortal" which came from the Latin "mors" (death). The opposite of mortality is, of course, immortality. Mortality is also quite distinct from morbidity (illness).
See the entire definition of Mortality

MRI: Abbreviation and nickname for magnetic resonance imaging. For more information, see: Magnetic Resonance Imaging; Paul C. Lauterbur; Peter Mansfield.

Mucous: Pertaining to mucus, a thick fluid produced by the lining of some tissues of the body.
See the entire definition of Mucous

Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle."

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Mycobacterium: A large family of bacteria that have unusually waxy cell walls that are resistant to digestion.
See the entire definition of Mycobacterium

Mycobacterium leprae: The bacillus responsible for leprosy (Hansen disease). Mycobacterium leprae is an obligate parasite that has to live within cells. There it is able to withstand the onslaught of enzymes and other forces by virtue of possessing a peculiarly resistant waxy coat and thanks also to its association with lowered cellular immunity. See also: Hansen disease.

Necrosis: The death of living cells or tissues. Necrosis can be due, for example, to ischemia (lack of blood flow). From the Greek "nekros" (dead body).

Necrotizing fasciitis: A dangerous infection of soft-tissue that starts in the subcutaneous tissue (just below the skin) and spreads along the flat layers of fibrous tissue that separate different layers of tissue (fascial planes). It most commonly occurs in the arms, legs and abdominal wall. The death rate is up to 40%.
See the entire definition of Necrotizing fasciitis

Nerve: A bundle of fibers that uses chemical and electrical signals to transmit sensory and motor information from one body part to another. See: Nervous system.

Neuropathy: Any and all disease or malfunction of the nerves.

NIH: The National Institutes of Health. The NIH is an important U.S. health agency. It is devoted to medical research. Administratively under the Department of Health and Human Services (HHS), the NIH consists of 20-some separate Institutes and Centers. NIH's program activities are represented by these Institutes and Centers.
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Numb: Numb, or numbness is a loss of the sensation of feeling in an area of the body. Numbness results from damage to, or impaired function of, the nerves that supply the affected area. The function of the nerves may be impaired by numerous causes including some chronic diseases ( diabetes mellitus , thyroid disease, migraine ), trauma , toxins, decreased blood supply due to atherosclerosis or other conditions, electrolyte imbalances, and pressure on the spinal nerves from herniated discs or other diseases of the spine .
See the entire definition of Numb

Obstruction: Blockage of a passageway. See, for example: Airway obstruction; Intestinal obstruction.

Operation: Although there are many meanings to the word "operation", in medicine it refers to a surgical procedure.
See the entire definition of Operation

Organ: A relatively independent part of the body that carries out one or more special functions. The organs of the human body include the eye, ear, heart, lungs, and liver.

Oxygen: A colorless, odorless and tasteless gas that makes up about 20% of the air we breathe (and at least half the weight of the entire solid crust of the earth) and which combines with most of the other elements to form oxides. Oxygen is essential to human, animal and plant life.
See the entire definition of Oxygen

Oxygenation: The addition of oxygen to any system, including the human body. Oxygenation may also refer to the process of treating a patient with oxygen, or of combining a medication or other substance with oxygen.
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Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia . Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
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Peripheral: Situated away from the center, as opposed to centrally located.
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Prognosis: 1. The expected course of a disease .
2. The patient's chance of recovery.
The prognosis predicts the outcome of a disease and therefore the future for the patient . His prognosis is grim, for example, while hers is good.
See the entire definition of Prognosis

Pus: A thick whitish-yellow fluid which results from the accumulation of white blood cells (WBCs), liquified tissue and cellular debris. Pus is commonly a site of infection or foreign material in the body.

Radiologic: Having to do with radiology.

Rehabilitation: The process of restoration of skills by a person who has had an illness or injury so as to regain maximum self-sufficiency and function in a normal or as near normal manner as possible. For example, rehabilitation after a stroke may help the patient walk again and speak clearly again.
See the entire definition of Rehabilitation

Residual: Something left behind. With residual disease, the disease has not been eradicated.
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Sensation: In medicine and physiology , sensation refers to the registration of an incoming ( afferent ) nerve impulse in that part of the brain called the sensorium , which is capable of such perception. Therefore, the awareness of a stimulus as a result of its perception by sensory receptors. (Sensory is here synonymous with sensation.)
See the entire definition of Sensation

Sepsis: Commonly called a "blood stream infection." The presence of bacteria (bacteremia) or other infectious organisms or their toxins in the blood (septicemia) or in other tissue of the body. Sepsis may be associated with clinical symptoms of systemic (bodywide) illness, such as fever , chills, malaise (generally feeling "rotten"), low blood pressure , and mental status changes. Sepsis can be a serious situation, a life threatening disease calling for urgent and comprehensive care.
See the entire definition of Sepsis

Septic: Infected, or denoting infection. For example, septic shock is shock caused by infection.

Staphylococcus: A group of bacteria that cause a multitude of diseases. Under a microscope, Staphylococcus bacteria are round and bunched together. They can cause illness directly by infection, or indirectly through products they make, such as the toxins responsible for food poisoning and toxic shock syndrome. The best known member of the Staphylococcus family is Staphylococcus aureus. Staphylococcus are the main culprit in hospital-acquired infections, and cause thousands of deaths every year.

Streptococcus: A group of bacteria, familiarly known as strep, that cause a multitude of diseases. The name comes from the Greek strepto- meaning twisted + kokkos meaning berry, and that is exactly what strep look like under the microscope, like a twisted bunch of little round berries. Illness caused by strep includes strep throat, strep pneumonia, scarlet fever, rheumatic fever (and rheumatic heart valve damage), glomerulonephritis, the skin disorder erysipelas, and PANDAS.

Supportive care: Treatment given to prevent, control, or relieve complications and side effects and to improve the patient's comfort and quality of life.

Surgeon: A physician who treats disease, injury, or deformity by operative or manual methods. A medical doctor specialized in the removal of organs, masses and tumors and in doing other procedures using a knife (scalpel). The definition of a "surgeon" has begun to blur in recent years as surgeons have begun to minimize the cutting, employ new technologies that are "minimally invasive," use scopes, etc.
See the entire definition of Surgeon

Surgery: The word "surgery" has multiple meanings. It is the branch of medicine concerned with diseases and conditions which require or are amenable to operative procedures. Surgery is the work done by a surgeon. By analogy, the work of an editor wielding his pen as a scalpel is s form of surgery. A surgery in England (and some other countries) is a physician's or dentist's office.
See the entire definition of Surgery

Therapeutic: Relating to therapeutics , that part of medicine concerned specifically with the treatment of disease . The therapeutic dose of a drug is the amount needed to treat a disease.
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Therapy: The treatment of disease .
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Tobacco: A South American herb, formally known as Nicotiana tabacum , whose leaves contain 2-8% nicotine and serve as the source of smoking and smokeless tobacco .
See the entire definition of Tobacco

Trauma: Any injury , whether physically or emotionally inflicted. "Trauma" has both a medical and a psychiatric definition. Medically, "trauma" refers to a serious or critical bodily injury, wound, or shock . This definition is often associated with trauma medicine practiced in emergency rooms and represents a popular view of the term. In psychiatry , "trauma" has assumed a different meaning and refers to an experience that is emotionally painful, distressful, or shocking, which often results in lasting mental and physical effects.
See the entire definition of Trauma

Vascular: Relating to the blood vessels of the body. The blood vessels of the body, as a group, are referred to as the vascular system.
See the entire definition of Vascular

Vasculitis: Plural: vasculitides. A general term for a group of diseases that feature inflammation of the blood vessels. Each of these diseases is defined by characteristic distributions of blood vessel involvement, patterns of organ involvement, and laboratory test abnormalities. The causes of these vasculitis diseases are usually not known, but immune system abnormality is a common feature.
See the entire definition of Vasculitis

Viable: Capable of life. For example, a viable premature baby is one who is able to survive outside the womb.

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Escherichia coli (E. coli) is a bacterium that commonly lives in the intestines of people and animals. There are many strains (types) of E. coli. Most of the E. coli are normal inhabitants of the small intestine and colon and are non-pathogenic, meaning they do not cause disease in the intestines. Nevertheless, these non-pathogenic E. coli can cause disease if they spread outside of the intestines, for example, into the urinary tract (where they cause bladder or kidney infections) or into the blood stream (sepsis).

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