Gamma-Hydroxybutyrate (Ghb)

How does Gamma-hydroxybutyrate (ghb) work?

The natural function of GHB in the body might be to slow down brain activity during sleep. Gamma hydroxybutyrate affects several nerve pathways in the brain, including activating the body's pain-killing (opioid) system and raising levels of growth hormone. 

Are there safety concerns?

The prescription medication Gamma hydroxybutyrate (sodium oxybate) is possibly safe for adults who are taking it for symptoms of a condition called narcolepsy, under close medical supervision.

Gamma hydroxybutyrate (GHB) is UNSAFE and illegal for use as a dietary supplement. Use of GHB, or the closely related gamma butyrolactone (GBL) and butanediol (BD), has been linked to at least three deaths and 122 cases of serious side effects. GHB can cause many serious side effects including headaches, hallucinations, dizziness, confusion, nausea, vomiting, drowsiness, agitation, diarrhea, sexual arousal, numbing of legs, vision problems, tightness of chest, mental changes, combativeness, memory loss, serious breathing and heart problems, seizures, coma, and death. Long-term use may lead to withdrawal symptoms.

Do not use gamma hydroxybutyrate if:
  • You are pregnant or breast-feeding.
  • You have epilepsy or a seizure disorder.
  • You have high blood pressure or an irregular heartbeat.
  • You are scheduled for surgery in the next two weeks. GHB might cause excessive sedation if combined with medications used during and after surgery.

Therapeutic Research Faculty copyright

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.