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February 9, 2012

Gallbladder Cancer

Weight Gain & Cancer Risk

Medical Author: Melissa Conrad Stöppler, MD
Medical Editor: William C. Shiel Jr., MD, FACP, FACR

Could weight gain increase your risk for gallbladder cancer?Excess weight is a known risk factor for many chronic diseases, such as diabetes and heart disease. Obesity has also been linked an increased risk for developing some cancers. To clarify the effects of weight gain on cancer risk, researchers in 2007 conducted an analysis of many studies reported in medical journals that describe 282,137 cases of cancer. The researchers wanted to see if weight gain had an effect on the risk for certain cancer types.

In particular, the researchers looked at the risk of cancer associated with a weight gain corresponding to an increase of 5 kg/m2 in body mass index (BMI). In terms of actual pounds gained, a man with a normal-range BMI of 23 would need to gain 15 kg (33 lbs.) of weight, while a woman with a BMI of 23 would need to gain 13 kg (28.6 lbs.) to correspond to an increase of 5 in the BMI.

The results, published in the Lancet in February 2008, revealed that weight gain is positively associated with the risk of developing a variety of types of cancer as described below.

For women, a weight gain corresponding to an increase of 5 in the BMI resulted in a significant increase in risk for developing four cancer types:

Gallbladder cancer is a disease in which malignant (cancer) cells form in the tissues of the gallbladder.

Gallbladder cancer is a rare disease in which malignant (cancer) cells are found in the tissues of the gallbladder. The gallbladder is a pear-shaped organ that lies just under the liver in the upper abdomen. The gallbladder stores bile, a fluid made by the liver to digest fat. When food is being broken down in the stomach and intestines, bile is released from the gallbladder through a tube called the common bile duct, which connects the gallbladder and liver to the first part of the small intestine.

The wall of the gallbladder has 3 main layers of tissue.

  • Mucosal (innermost) layer.


  • Muscularis (middle, muscle) layer.


  • Serosal (outer) layer.

Between these layers is supporting connective tissue. Primary gallbladder cancer starts in the innermost layer and spreads through the outer layers as it grows.

Being female can increase the risk of developing gallbladder cancer.

Anything that increases your chance of getting a disease is called a risk factor. Risk factors for gallbladder cancer include the following:

  • Being female.


  • Being Native American.

Possible signs of gallbladder cancer include jaundice, pain, and fever.

These and other symptoms may be caused by gallbladder cancer. Other conditions may cause the same symptoms. A doctor should be consulted if any of the following problems occur:




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    • Abdominal Pain
      • Abdominal pain is pain in the belly and can be acute or chronic. Causes include inflammation, distention of an organ, and loss of the blood supply to an organ. Abdominal pain can reflect a major problem with one of the organs in the abdomen such as the appendix, gallbladder, large and small intestine, pancreas, liver, colon, duodenum, and spleen.
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      • Gallstones are stones that form when substances in the bile harden. Gallstones (formed in the gallbladder) can be as small as a grain of sand or as large as a golf ball. There can be just one large stone, hundreds of tiny stones, or any combination. The majority of gallstones do not cause symptoms.
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      • Jaundice is a yellowish staining of the skin and whites of the eyes (sclerae) with bilirubin, the pigment found in bile. Jaundice can be an indicator of liver or gallbladder disease, or it may result from the rupture of red blood cells (hemolysis).
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