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November 8, 2009
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Gallbladder Cancer

Weight Gain & Cancer Risk

Medical Author: Melissa Conrad Stöppler, MD
Medical Editor: William C. Shiel Jr., MD, FACP, FACR

Could weight gain increase your risk for gallbladder cancer?Excess weight is a known risk factor for many chronic diseases, such as diabetes and heart disease. Obesity has also been linked an increased risk for developing some cancers. To clarify the effects of weight gain on cancer risk, researchers in 2007 conducted an analysis of many studies reported in medical journals that describe 282,137 cases of cancer. The researchers wanted to see if weight gain had an effect on the risk for certain cancer types.

In particular, the researchers looked at the risk of cancer associated with a weight gain corresponding to an increase of 5 kg/m2 in body mass index (BMI). In terms of actual pounds gained, a man with a normal-range BMI of 23 would need to gain 15 kg (33 lbs.) of weight, while a woman with a BMI of 23 would need to gain 13 kg (28.6 lbs.) to correspond to an increase of 5 in the BMI.

The results, published in the Lancet in February 2008, revealed that weight gain is positively associated with the risk of developing a variety of types of cancer as described below.

For women, a weight gain corresponding to an increase of 5 in the BMI resulted in a significant increase in risk for developing four cancer types:

Gallbladder cancer is a disease in which malignant (cancer) cells form in the tissues of the gallbladder.

Gallbladder cancer is a rare disease in which malignant (cancer) cells are found in the tissues of the gallbladder. The gallbladder is a pear-shaped organ that lies just under the liver in the upper abdomen. The gallbladder stores bile, a fluid made by the liver to digest fat. When food is being broken down in the stomach and intestines, bile is released from the gallbladder through a tube called the common bile duct, which connects the gallbladder and liver to the first part of the small intestine.

The wall of the gallbladder has 3 main layers of tissue.

  • Mucosal (innermost) layer.


  • Muscularis (middle, muscle) layer.


  • Serosal (outer) layer.

Between these layers is supporting connective tissue. Primary gallbladder cancer starts in the innermost layer and spreads through the outer layers as it grows.

Being female can increase the risk of developing gallbladder cancer.

Anything that increases your chance of getting a disease is called a risk factor. Risk factors for gallbladder cancer include the following:

  • Being female.


  • Being Native American.

Possible signs of gallbladder cancer include jaundice, pain, and fever.

These and other symptoms may be caused by gallbladder cancer. Other conditions may cause the same symptoms. A doctor should be consulted if any of the following problems occur:



Next: What exams and tests are used to diagnose gallbladder cancer? »

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Gallbladder Cancer

What is a fever?

Fever refers to an elevation in body temperature. Technically, any body temperature above the normal oral measurement of 98.6 F (37 C) or the normal rectal temperature of 99 F (37.2 C) is considered to be elevated. However, these are averages, and your normal temperature may actually be 1 F (0.6 C) or more above or below the average of 98.6 F. Body temperature can also vary up to 1 F (0.6 C) throughout the day.

Thus, fever is not considered medically significant until body temperature is above 100.4 F (38 C). Fever serves as one of the body's natural defenses against bacteria and viruses which cannot live at a higher temperature. For that reason, low fevers should normally go untreated, unless accompanied by troubling symptoms.

Also, the body's defense mechanisms seem to work more efficiently at a higher temperature. Fever is just one part of an illness, many times no more important than the presence of other symptoms such as cough, ...

Read the Fever article »










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