gabapentin enacarbil, Horizant

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GENERIC NAME: gabapentin enacarbil

BRAND NAME: Horizant

DRUG CLASS AND MECHANISM: Gabapentin enacarbil is used for treating restless leg syndrome (RLS) and postherpetic neuralgia. It is a prodrug of the anticonvulsant gabapentin, which means it is first converted to gabapentin in the body before it can have its effects. The mechanism of action of gabapentin in treating restless leg syndrome (RLS) or postherpatic neuralgia is not known. Gabapentin structurally resembles the neurotransmitter, gamma aminobutyric acid (GABA). (A neurotransmitter is a chemical that nerves use to communicate with one another.) It is possible that this similarity is related to gabapentin's mechanism of action. In animal models used for testing the anti-seizure and anti-pain (analgesic) activities of drugs, gabapentin prevents seizures and reduces pain-related responses. The FDA approved gabapentin enacarbil in April 2011.

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

PREPARATIONS: Tablets (extended release): 300, 600 mg

STORAGE: Gabapentin enacarbil should be store between 15 C to 30 C (59 F to 86 F).

PRESCRIBED FOR: Gabapentin enacarbil is approved for treating nerve damage from herpes zoster (shingles, postherpetic neuralgia), and restless leg syndrome.

Medically Reviewed by a Doctor on 2/11/2014



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