Table of Contents
- Introduction to fungal nails (onychomycosis, tinea unguium)
- What other conditions can be mistaken for fungal nails?
- What causes fungal nails, and what are some of the risk factors?
- Are fungal nails contagious?
- What are fungal nail symptoms and signs?
- What tests do health-care professionals use to diagnose fungal nails?
- Who should be treated for fungal nails?
- What specialists treat nail fungus?
- What is the treatment for fungal nails?
- What is the treatment for fungal nails? (Continued)
- Are there home remedies for toenail fungus?
- Are there over-the-counter treatments for toenail fungus?
- Are oral medications for nail fungus toxic?
- What about the cost of oral medications for fungal nails?
- Is it possible to prevent fungal nails?
- What is the prognosis of fungal nails?
- Is it possible to prevent the recurrence of nail fungus?
- Tips for prevention of fungal nails
Quick GuideNail Color and Texture: What Nails Say About Your Health
What are fungal nail symptoms and signs?
Although fungal nails are usually cosmetic concerns, some patients do experience pain and discomfort. These symptoms may be exacerbated by footwear, activity, and improper trimming of the nails.
There are many species of fungi that can affect nails. By far the most common, however, is called Trichophyton rubrum (T. rubrum). This type of fungus has a tendency to infect the skin (known as a dermatophyte) and manifests in the following specific ways.
- Starts at the ends of the nails and raises the nail up: This is called "distal subungual onychomycosis." It is the most common type of fungal infection of the nails in both adults and children (90% of cases). It is more common in the toes than the fingers, and the great toe is usually the first one to be affected. Risk factors include older age, swimming, athlete's foot, psoriasis, diabetes, family members with the infection, or a suppressed immune system. It usually starts as a discolored area at a corner of the big toe and slowly spreads toward the cuticle. Eventually, the toenails will become thickened and flaky. Sometimes, you can also see signs of athlete's foot in between the toes or skin peeling on the sole of the foot. It is often accompanied by onycholysis. The most common cause is T. rubrum.
- Starts at the base of the nail and raises the nail up: This is called "proximal subungual onychomycosis." This is the least common type of fungal nail (about 3% of cases). It is similar to the distal type, but it starts at the cuticle (base of the nail) and slowly spreads toward the nail tip. This type almost always occurs in people with a damaged immune system. It is rare to see debris under the tip of the nail with this condition, unlike distal subungual onychomycosis. The most common cause is T. rubrum and non-dermatophyte molds.
- Yeast onychomycosis: This type is caused by a yeast called Candida and not by the Trichophyton fungus named above. It is more common in fingernails and is a common cause of fungal fingernails. Patients may have associated paronychia (infection of the cuticle). Candida can cause yellow, brown, white, or thickened nails. Some people who have this infection also have yeast in their mouth or have a chronic paronychia (see above) that is also infected with yeast.
- White superficial onychomycosis: In this nail condition, a doctor can often scrape off a white powdery material on the top of the nail plate. This condition is most common in tropical environments and is caused by a fungus known and Trichophyton mentagrophytes.
Baran, R., R.J. Hay, and J.I. Garduno. "Review of Antifungal Therapy, Part II: Treatment Rationale, Including Specific Patient Populations." J Dermatolog Treat 19.3 (2008): 168-175.
Brillowska-Dabrowska, A., S.S. Nielsen, H.V. Nielsen, and M.C. Arendrup. "Optimized 5-Hour Multiplex PCR Test for the Detection of Tinea Unguium: Performance in a Routine PCR Laboratory." Med Mycol. 48.6 Sept. 2010: 828-831.
Bristow, I.R., and M.C. Spruce. "Fungal Foot Infection, Cellulitis and Diabetes: A Review." Diabet Med 26 (2009): 548.
de Berker, D. "Clinical Practice. Fungal Nail Disease." N Engl J Med. 360.20 May 14, 2009: 2108-2116.
Derby, R., P. Rohal, C. Jackson, et al. "Novel Treatment of Onychomycosis Using Over-the-Counter Mentholated Ointment: A Clinical Case Series." J Am Board Fam Med 24 (2011): 69.
Gaburri, D., J.M. Chebli, A. Zanine, A.C. Gamonal, and P.D. Gaburri. "Onychomycosis in Inflammatory Bowel Diseases." J Eur Acad Dermatol Venereol. 22.7 JulY 2008: 807-812.
Garcia-Doval, I., et al. "Clinical Diagnosis of Toenail Onychomycosis Is Possible in Some Patients: Cross-sectional Diagnostic Study and Development of a Diagnostic Rule." Br J Dermatol. 163.4 Oct. 2010: 743-751.
Ginarte, M., Garcia-Doval, I., et al. "Observer Agreement in Toenail Disorders: Implications for Diagnosis and Clinical Research." Br J Dermatol. 160.6 June 2009: 1315-1317.
Gupta, A.K., L.E. Lynch, N. Kogan, and E.A. Cooper. "The Use of an Intermittent Terbinafine Regimen for the Treatment of Dermatophyte Toenail Onychomycosis." J Eur Acad Dermatol Venereol. 23.3 Mar. 2009: 256-262.
Kondori, N., A.L. Abrahamsson, N. Ataollahy, and C. Wennerås. "Comparison of a New Commercial Test, Dermatophyte-PCR Kit, With Conventional Methods for Rapid Detection and Identification of Trichophyton rubrum in Nail Specimens." Med Mycol. 48.7 Nov. 2010: 1005-1008.
Litz, C.E., and R.Z. Cavagnolo. "Polymerase Chain Reaction in the Diagnosis of Onychomycosis: A Large, Single-Institute Study." Br J Dermatol. 163.3 Sept. 2010: 511-514.
Nair, A.B., S.R. Vaka, S.M. Sammeta, H.D. Kim, P.M. Friden, B. Chakraborty, and S.N. Murthy. "Trans-ungual Iontophoretic Delivery of Terbinafine." J Pharm Sci. 98.5 May 2009: 1788-1796.
Shemer, A., B. Davidovici, M.H. Grunwald, H. Trau, and B. Amichai. "Comparative Study of Nail Sampling Techniques in Onychomycosis." J Dermatol. 36.7 Jul7 2009: 410-414.
Shemer, A., H. Trau, B. Davidovici, M.H. Grunwald, and B. Amichai. "Onychomycosis in Psoriatic Patients - Rationalization of Systemic Treatment." Mycoses. 53.4 July 2010: 340-343.
Sigurgeirsson, B., J.H. Olafsson, J.T. Steinsson, N. Kerrouche, and F. Sidou. "Efficacy of Amorolfine Nail Lacquer for the Prophylaxis of Onychomycosis Over 3 Years." J Eur Acad Dermatol Venereol. 24.8 Aug. 2010: 910-915.
Smijs, T.G., and S. Pavel. "The Susceptibility of Dermatophytes to Photodynamic Treatment With Special Focus on Trichophyton rubrum." Photochem Photobiol. 87.1 Jan.-Feb. 2011: 2-13.
Sotiriou, E., T. Koussidou-Eremonti, G. Chaidemenos, Z. Apalla, and D. Ioannides. "Photodynamic Therapy for Distal and Lateral Subungual Toenail Onychomycosis Caused by Trichophyton rubrum: Preliminary Results of a Single-Centre Open Trial." Acta Derm Venereol. 90.2 Mar. 2010: 216-217.
Takahata, Y., M. Hiruma, Y. Shiraki, Y. Tokuhisa, T. Sugita, and M. Muto. "Treatment of Dermatophyte Onychomycosis With Three Pulses of Terbinafine (500 mg Day for a Week)." Mycoses. 52.1 Jan. 2009: 72-76.
Thomas, J., et al. "Toenail Onychomycosis: An Important Global Disease Burden." J Clin Pharm Ther. 35.5 Oct. 2010: 497-519.
Walling, H.W. "Subclinical Onychomycosis Is Associated With Tinea Pedis." Br J Dermatol. 161.4 Oct. 2009: 746-749.
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