Nail Fungus Treatment
Onychomycosis is a fungal infection usually caused by a special type of fungus known as a dermatophyte.
Since most of these infections are relatively superficial, it would seem that topical treatments ought to work well. This is not the case because the nail unit is relatively impenetrable.
Quick GuideNail Color and Texture: What Nails Say About Your Health
Introduction to fungal nails (onychomycosis, tinea unguium)
Many changes in fingernails or toenails may cause people to think they have a fungal infection of the nails, medically known as onychomycosis.
Fungal infection of the nails sometimes makes the condition sound contagious or related to poor hygiene. In fact, up to 10% of all adults in Western countries have fungal infection of the nails. This percentage increases to 20% of adults who are age 60 or older. Toenail fungus is much more common than fingernail fungus.
In reality, abnormal-looking nails may be caused by a number of conditions including, but not limited to, fungal infection. There are many other reasons why your nails may look different.
Reviewed on 3/8/2016
Averill, R.W., and R.K. Scher. "Simplified Nail Taping With Urea Ointment for Nonsurgical Nail Avulsion." Cutis 38 (1986): 231.
Baran, R., R.J. Hay, and J.I. Garduno. "Review of Antifungal Therapy, Part II: Treatment Rationale, Including Specific Patient Populations." J Dermatolog Treat 19.3 (2008): 168-175.
Brillowska-Dabrowska, A., S.S. Nielsen, H.V. Nielsen, and M.C. Arendrup. "Optimized 5-Hour
Multiplex PCR Test for the Detection of Tinea Unguium: Performance in a Routine PCR
Med Mycol. 48.6 Sept. 2010: 828-831.
Bristow, I.R., and M.C. Spruce. "Fungal Foot Infection, Cellulitis and Diabetes: A Review." Diabet Med 26 (2009): 548.
de Berker, D. "Clinical Practice. Fungal Nail Disease." N Engl J Med. 360.20 May 14, 2009: 2108-2116.
Derby, R., P. Rohal, C. Jackson, et al. "Novel Treatment of Onychomycosis Using Over-the-Counter Mentholated Ointment: A Clinical Case Series." J Am Board Fam Med 24 (2011): 69.
Elewski, B.E. "The Effect of Toenail Onychomycosis on Patient Quality of Life." Int J Dermatol 36 (1997): 7.
Gaburri, D., J.M. Chebli, A. Zanine, A.C. Gamonal, and P.D. Gaburri. "Onychomycosis in
Inflammatory Bowel Diseases."
J Eur Acad Dermatol Venereol. 22.7 JulY 2008: 807-812.
Garcia-Doval, I., et al. "Clinical Diagnosis of Toenail Onychomycosis Is Possible in
Some Patients: Cross-sectional Diagnostic Study and Development of a Diagnostic
Br J Dermatol. 163.4 Oct. 2010: 743-751.
Ginarte, M., Garcia-Doval, I., et al. "Observer Agreement in Toenail Disorders:
Implications for Diagnosis and Clinical Research."
Br J Dermatol. 160.6 June 2009: 1315-1317.
Grover, C., S. Bansal, S. Nanda, et al. "Combination of Surgical Avulsion and Topical Therapy for Single Nail Onychomycosis: A Randomized Controlled Trial." Br J Dermatol 157 (2007): 364.
Gupta, A.K., H.C. Jain, C.W. Lynde, P. Macdonald, E.A. Cooper, and R.C. Summerbell. "Prevalence and
Epidemiology of Onychomycosis in Patients Visiting Physician's Offices: A Multicenter Canadian
Survey of 15,000 Patients." J Am Acad Dermatol 43 (2 Pt 1) (2000): 244.
Gupta, A.K., L.E. Lynch, N. Kogan, and E.A. Cooper. "The Use of an Intermittent
Terbinafine Regimen for the Treatment of Dermatophyte Toenail Onychomycosis."
J Eur Acad Dermatol Venereol. 23.3 Mar. 2009: 256-262.
Kondori, N., A.L. Abrahamsson, N. Ataollahy, and C. Wennerås. "Comparison of a
New Commercial Test, Dermatophyte-PCR Kit, With Conventional Methods for Rapid Detection and
Identification of Trichophyton rubrum in Nail Specimens." Med Mycol. 48.7 Nov. 2010: 1005-1008.
Litz, C.E., and R.Z. Cavagnolo. "Polymerase Chain Reaction in the Diagnosis of Onychomycosis:
A Large, Single-Institute Study." Br J Dermatol. 163.3 Sept. 2010: 511-514.
Montgomery, B.J. "Urea Plasters Alternative to Surgery for Nail Removal." JAMA 241 (1979): 1559, 1563.
Nair, A.B., S.R. Vaka, S.M. Sammeta, H.D. Kim, P.M. Friden, B. Chakraborty, and S.N. Murthy. "Trans-ungual
Iontophoretic Delivery of Terbinafine."
J Pharm Sci. 98.5 May 2009: 1788-1796.
Roujeau, J.C., B. Sigurgeirsson, H.C. Korting, et al. "Chronic Dermatomycoses of the Foot as Risk Factors for Acute Bacterial Cellulitis of the Leg: A Case-Control Study." Dermatology 209 (2004): 301.
Shemer, A., B. Davidovici, M.H. Grunwald, H. Trau, and B. Amichai. "Comparative
Study of Nail Sampling Techniques in Onychomycosis."
J Dermatol. 36.7 Jul7 2009: 410-414.
Shemer, A., H. Trau, B. Davidovici, M.H. Grunwald, and B. Amichai. "Onychomycosis in
Psoriatic Patients - Rationalization of Systemic Treatment."
Mycoses. 53.4 July 2010: 340-343.
Sigurgeirsson, B., J.H. Olafsson, J.T. Steinsson, N. Kerrouche, and F. Sidou. "Efficacy of
Amorolfine Nail Lacquer for the Prophylaxis of Onychomycosis Over 3 Years."
J Eur Acad Dermatol Venereol. 24.8 Aug. 2010: 910-915.
Sigurgeirsson, B., and O. Steingrímsson. "Risk Factors Associated With Onychomycosis." J Eur Acad Dermatol Venereol 18 (2004): 48.
Smijs, T.G., and S. Pavel. "The Susceptibility of Dermatophytes to Photodynamic
Treatment With Special Focus on Trichophyton rubrum."
Photochem Photobiol. 87.1 Jan.-Feb. 2011: 2-13.
Sotiriou, E., T. Koussidou-Eremonti, G. Chaidemenos, Z. Apalla, and D. Ioannides. "Photodynamic
Therapy for Distal and Lateral Subungual Toenail Onychomycosis Caused by Trichophyton rubrum: Preliminary
Results of a Single-Centre Open Trial."
Acta Derm Venereol. 90.2 Mar. 2010: 216-217.
Szepietowski, J.C., A. Reich, E. Garlowska, et al. "Factors Influencing Coexistence of Toenail Onychomycosis With Tinea Pedis and Other Dermatomycoses: A Survey of 2761 Patients." Arch Dermatol 142 (2006): 1279.
Takahata, Y., M. Hiruma, Y. Shiraki, Y. Tokuhisa, T. Sugita, and M. Muto. "Treatment of
Dermatophyte Onychomycosis With Three Pulses of Terbinafine (500 mg Day for a Week)."
Mycoses. 52.1 Jan. 2009: 72-76.
Thomas, J., et al. "Toenail Onychomycosis: An Important Global Disease Burden."
J Clin Pharm Ther. 35.5 Oct. 2010: 497-519.
Tosti, A., B.M. Piraccini, C. Stinchi, and M.D. Colombo. "Relapses of Onychomycosis After Successful Treatment With Systemic Antifungals: A Three-Year Follow-up." Dermatology 197 (1998): 162.
Walling, H.W. "Subclinical Onychomycosis Is Associated With Tinea Pedis." Br J Dermatol. 161.4 Oct. 2009: 746-749.
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