fosinopril sodium, Monopril (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Fosinopril can cause an increase in the amount of lithium (Eskalith, Lithobid) in the body in patients taking lithium, sometimes causing lithium-associated side effects.
Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, Medipren, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ACE inhibitors on blood pressure. Combining fosinopril or other ACE inhibitors with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, volume-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible. Nitritoid reactions (symptoms include facial flushing, nausea, vomiting, and hypotension) may occur when injectable gold sodium aurothiomalate (Myochrysine), used in the treatment of rheumatoid arthritis, is combined with ACE inhibitors, including fosinopril.
PREGNANCY: ACE inhibitors, including fosinopril, can be harmful to the fetus and should not be taken by pregnant women.
NURSING MOTHERS: Fosinopril is secreted in breast milk and is not recommended for nursing mothers.
SIDE EFFECTS: Fosinopril is generally well tolerated. The most common side effects are headache, cough, dizziness, diarrhea, fatigue, nausea, vomiting, and increase in potassium levels. Sexual dysfunction and abnormal liver tests also occur. Impairment of kidney function has been reported with ACE inhibitors, especially in patients with severe heart failure or kidney disease. Serious, but fortunately very rare side effects include liver failure, low white blood cell counts (neutropenia) and angioedema (swelling of lips and throat that can obstruct breathing).
Reference: FDA Prescribing Information
Last Editorial Review: 5/3/2012
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