fluvoxamine, Luvox, Luvox CR (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Fluvoxamine can inhibit the elimination of clozapine (Clozaril), necessitating dosage reductions of clozapine.

Fluvoxamine also may inhibit the elimination and increase the blood levels of theophylline (Theodur, Uniphyl), alprazolam (Xanax), and triazolam (Halcion) leading to side effects from these drugs.

Fluvoxamine may increase the effect of warfarin (Coumadin), leading to excessive bleeding. Warfarin therapy should be monitored more frequently in patients who also are taking fluoxetine.

Combining SSRIs with aspirin, nonsteroidal anti-inflammatory drugs or other drugs that affect bleeding may increase the likelihood of upper gastrointestinal bleeding. Fluvoxamine may increase blood levels of tizanidine (Zanaflex), thioridazine (Mellaril), alosetron (Lotronex), and pimozide (Orap), leading to increased side effects of these drugs.

PREGNANCY: There are no adequate studies of fluvoxamine in pregnant women. Infants exposed to SSRIs in late pregnancy may have an increased risk for persistent pulmonary hypertension of the newborn (PPHN), which can be fatal.

NURSING MOTHERS: Fluvoxamine is excreted into breast milk. There are no adequate studies in lactating women.

SIDE EFFECTS: Side effects of fluvoxamine include anxiety, nervousness, sweating, nausea, decreased appetite, constipation, diarrhea, dry mouth, somnolence (sleepiness), dizziness, insomnia, and sexual disfunction. Fluvoxamine also may cause abnormal bleeding, seizures, and manic episodes. Withdrawal of fluvoxamine may result in withdrawal symptoms. The most common symptoms of withdrawal are dizziness, tiredness, tingling of the extremities, nausea, vivid dreams, irritability, and poor mood. Other symptoms include visual disturbances and headaches.

Medically Reviewed by a Doctor on 5/31/2013


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