- Tablets: 25, 50 and 100 mg.
- Tablets (extended release): 100 and 150 mg.
- All SSRIs, including fluvoxamine, should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane) other drugs that inhibit monoamine oxidase such as linezolid (Zyvox) and intravenous methylene blue. Such combinations may lead to confusion, high blood pressure, tremor, and increased activity. Fluvoxamine should not be administered within 14 days of discontinuing an MAO inhibitor, and MAO inhibitors should not be administered within 14 days of stopping fluvoxamine. Similar reactions occur if fluvoxamine is combined with other drugs, for example, tryptophan, St. John's wort, meperidine (Demerol), and tramadol (Ultram) that increase serotonin in the brain.
- Fluvoxamine can inhibit the elimination of clozapine (Clozaril), necessitating dosage reductions of clozapine.
- Fluvoxamine also may inhibit the elimination and increase the blood levels of theophylline (Theodur, Uniphyl), alprazolam (Xanax), and triazolam (Halcion) leading to side effects from these drugs.
- Fluvoxamine may increase the effect of warfarin (Coumadin, Jantoven), leading to excessive bleeding. Warfarin therapy should be monitored more frequently in patients who also are taking fluoxetine.
- Combining SSRIs with aspirin, nonsteroidal anti-inflammatory drugs or other drugs that affect bleeding may increase the likelihood of upper gastrointestinal bleeding. Fluvoxamine may increase blood levels of tizanidine (Zanaflex), thioridazine (Mellaril), alosetron (Lotronex), and pimozide (Orap), leading to increased side effects of these drugs.
Quick GuideDepression Hurts: Physical Symptoms of Depression
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