fluvastatin, Lescol, Lescol XL (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Statins may cause liver damage although serious liver damage is rare. Blood liver tests should be performed at the beginning of treatment and as needed thereafter to detect liver injury.
Statins have been associated with increases in HbA1c and fasting serum glucose levels.
There are also post-marketing reports of memory loss, forgetfulness, amnesia, confusion, and memory impairment. Symptoms may start one day to years after starting treatment and resolve within a median of three weeks after stopping the statin.
GENERIC AVAILABLE: Yes
PREPARATIONS: Capsules: 20 and 40 mg. Tablets (Extended Release): 80 mg
STORAGE: Tablets should be stored at room temperature 15 C - 30 C (59 F - 86 F) in a tightly closed container.
DOSING: The recommended dose range is 20 to 80 mg daily. Fluvastatin may be given once in the evening or twice daily. It may be taken on an empty or full stomach. Fluvastatin extended release can be administered at anytime of the day. Two 40 mg capsules should not be administered at one time.
DRUG INTERACTIONS: Cyclosporine and fluconazole (Diflucan) increase blood levels of fluvastatin. Therefore, the dose of fluvastatin should be limited to 20 mg twice daily when patients are also taking cyclosporine or fluconazole.
Gemfibrozil should not be combined with fluvastatin due to increased risk of muscle-related side effects when the two drugs are combined.
PREGNANCY: Fluvastatin may cause fetal harm and should not be taken by pregnant women.
NURSING MOTHERS: Fluvastatin should not be used by nursing mothers because of potential adverse side effects to the nursing infant.
Medically reviewed by Eni Williams, PharmD
Reference: FDA Prescribing Information
Medically Reviewed by a Doctor on 5/22/2015
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