fluticasone propionate oral inhaler, Flovent (Discontinued), Flovent Diskus, Flovent HFA (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
DOSING: Doses vary from patient to patient.
The recommended dose for the aerosol is 88 to 440 mcg twice daily.
The recommended dose for the Diskhaler is 100 to 1000 mcg twice daily. Following administration, the mouth should be rinsed thoroughly with water or mouthwash to minimize dry mouth, irritation of the throat, and hoarseness.
The aerosol inhaler must be cleaned at least once a week.
If a bronchodilator aerosol spray (a spray that causes the airways to expand), for example, albuterol (Proventil; Ventolin), is used, it should be used first, and then 5-15 minutes later fluticasone should be used.
DRUG INTERACTIONS: Ritonavir (Norvir), atazanavir (Reyataz), clarithromycin (Biaxin), indinavir (Crixivan), itraconazole (Sporanox), ketoconazole, nelfinavir (Viracept), and telithromycin (Ketek) may increase levels of fluticasone in the body by reducing the breakdown of fluticasone by liver enzymes. This may increase side effects of fluticasone.
PREGNANCY: Adequate studies of fluticasone during pregnancy have not been done. Fluticasone use during pregnancy should be avoided unless the potential benefit justifies the potential but unknown risk to the fetus.
NURSING MOTHERS: It is not known if fluticasone is secreted in breast milk. Other medications in the same class as fluticasone are secreted into breast milk. It is not known whether the small amounts that may appear in the milk affect the infant.
SIDE EFFECTS: The most common side effects of fluticasone are headache, upper respiratory infections, throat irritation, nasal congestion, nasal discharge, and hoarseness or difficulty speaking. Fluticasone may also cause bronchospasms (wheezing). Bronchospasms should be treated with a rescue inhaler.
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