fluticasone and salmeterol oral inhaler, Advair Diskus, Advair HFA (cont.)

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Advair contains a combination of salmeterol, a bronchodilator of the beta-2 agonist type, and fluticasone propionate, an anti-inflammatory corticosteroid. Beta-2 agonists are medications that attach to beta-2 receptors on the smooth muscle cells that surround the airways, causing the muscle cells to relax and open the airways. Fluticasone propionate is a synthetic (man-made) corticosteroid of the glucocorticoid family which is related to the natural hormone, cortisol or hydrocortisone, produced by the adrenal glands. Glucocorticoid steroids have potent anti-inflammatory actions. In asthmatic patients, the suppression of inflammation within the airways reduces the swelling caused by inflammation that narrows the airways. At the same time, production of mucus is reduced. When used in lower doses, very little inhaled fluticasone propionate is absorbed into the body and side effects are infrequent. When higher doses are used, fluticasone is absorbed and may cause side effects elsewhere in the body. The FDA approved Advair Diskus in August, 2000 and Advair HFA in June 2006.

PRESCRIBED FOR: Advair Diskus is used for the treatment of asthma or chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis. Its action starts within 30 to 60 minutes and can last more than 12 hours. Advair Diskus is generally not needed in patients whose asthma can be controlled easily with infrequent administration of short acting inhalers. Advair HFA is used for treating asthma in individuals 12 years old or older. Advair Diskus or HFA should not be used to treat acute episodes of asthma or COPD.

SIDE EFFECTS: Upper respiratory tract infections occur in 20% to 25% of patients using Advair. Headaches occur in about 1 in 8 patients who use it. Other potential adverse events include

Medically Reviewed by a Doctor on 2/11/2015

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