fluticasone nasal spray, Flonase

Pharmacy Author:
Medical and Pharmacy Editor:

GENERIC NAME: Fluticasone propionate, nasal spray

BRAND NAME: Flonase

DRUG CLASS AND MECHANISM: Fluticasone is a man-made corticosteroid. The exact mechanism of action of fluticasone is not known; however, it stimulates glucocorticoid receptors in humans that produces a potent anti-inflammatory response. Fluticasone also works on multiple cells and mediators that are responsible for the inflammatory symptoms of allergic rhinitis (sneezing, runny nose, etc). The FDA approved fluticasone in October 1994.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Fluticasone propionate nasal spray is available as a 16 gm bottle, providing a total of 120 sprays. Each spray contains 50 mcg of fluticasone propionate.

STORAGE: Fluticasone propionate should be store between 4 C and 30 C (39 F and 86 F).

PRESCRIBED FOR: Fluticasone is used for the management of nasal symptoms of seasonal or perennial, allergic and non-allergic rhinitis in adults and children of 4 years of age and older.

Safe and effective use of fluticasone has not been established for children under the age of 4.

DOSING:

  • Adults: The recommended dosing is 2 sprays per nostril daily. The maximum dose is 200 mcg/day (4 sprays).
  • Adolescents and Children 4 years of age and older: the recommended dosing is 1 spray per nostril daily that maybe increased to 2 sprays per nostril daily. The maximum dose is 200 mcg/day.

DRUG INTERACTIONS: Ritonavir (Norvir) and ketoconazole (Nizoral, Extina, Xolegel, Kuric) increase fluticasone levels in the body by delaying its metabolism (elimination). It is not clear how important this effect is.

PREGNANCY: There are no adequate studies of fluticasone to determine its safety and effectiveness in pregnant women.

NURSING MOTHERS: It is not known whether fluticasone enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.

SIDE EFFECTS: Side effects of fluticasone include headache, sore throat, nosebleeds, nasal burning or nasal irritation, nausea, vomiting, asthma symptoms or cough. Some children may experience growth suppression from use of inhaled steroids.

REFERENCES:
FDA Prescribing Information on Flonase.
Micromedex Drug Information™


Medically Reviewed by a Doctor on 4/16/2014



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.


Back to Medications Index