Fluticasone propionate, nasal spray (Flonase)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: Fluticasone propionate, nasal spray
BRAND NAME: Flonase
DRUG CLASS AND MECHANISM: Fluticasone is a man-made cortico-steroid. The exact mechanism of action of fluticasone is not known; however, it stimulates glucocorticoid receptors in humans which produces a potent anti-inflammatory response. Fluticasone also works on multiple cells and mediators that are responsible for the inflammatory symptoms of allergic rhinitis (sneezing, runny nose, etc). The FDA approved fluticasone in October 1994.
GENERIC AVAILABLE: Yes
PREPARATIONS: Fluticasone propionate nasal spray is available as a 16 gm bottle, providing a total of 120 sprays. Each spray contains 50 mcg of fluticasone propionate.
STORAGE: Fluticasone propionate should be store between 4 C and 30 C (39 F and 86 F).
PRESCRIBED FOR: Fluticasone is used for the management of nasal symptoms of seasonal or perennial, allergic and non-allergic rhinitis in adults and children of 4 years of age and older.
Safe and effective use of fluticasone has not been established for children under the age of 4.
DRUG INTERACTIONS: Ritonavir (Norvir) and ketoconazole (Nizoral, Extina, Xolegel, Kuric) increase fluticasone levels in the body by delaying its metabolism (elimination). It is not clear how important this effect is.
PREGNANCY: There are no adequate studies of fluticasone to determine its safety and effectiveness in pregnant women.
NURSING MOTHERS: It is not known whether fluticasone enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.
SIDE EFFECTS: Side effects of fluticasone include headache, sore throat (pharyngitis), nosebleed (epistaxis), nasal burning or nasal irritation, nausea, vomiting, asthma symptoms, or cough. Some children may experience growth suppression from use of inhaled steroids.
Last Editorial Review: 4/17/2014
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