flurbiprofen, Ansaid (discontinued brand) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
DOSING: The recommended dose is 50-100 mg 2 to 4 times daily. The maximum daily dose is 300 mg. Flurbiprofen should be taken with food to reduce stomach upset.
DRUG INTERACTIONS: Flurbiprofen is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of the increased risk of bleeding. Patients taking lithium (Lithobid, Eskalith) can develop toxic blood levels of lithium because flurbiprofen may inhibit the elimination of lithium from the body by the kidney.
Side effects from methotrexate (Trexall, Rheumatrex) and cyclosporine also may be increased by flurbiprofen.
Flurbiprofen may reduce the effectiveness of medications that are used for treating high blood pressure because it causes or worsens high blood pressure. NSAIDs may diminish the blood pressure-lowering effects of angiotensin converting enzyme (ACE) inhibitors. Combining NSAIDs with angiotensin receptor blockers (for example, valsartan [Diovan], losartan [Cozaar], irbesartan [Avapro]) or angiotensin converting enzyme inhibitors (for example, enalapril [Vasotec], captopril [Captoen]) in patients who are elderly, volume-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible.
Persons who have more than three alcoholic beverages per day are at increased risk of developing stomach ulcers when taking flurbiprofen or other NSAIDs.
PREGNANCY: Flurbiprofen is generally avoided during pregnancy.
Medically Reviewed by a Doctor on 2/17/2015
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