flurbiprofen, Ansaid (discontinued brand) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Flurbiprofen should be avoided by patients with a history of asthma attacks, hives, or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with peptic ulcer disease or poor kidney function, since this medication can aggravate both conditions. Like other NSAIDS flurbiprofen may cause heart attacks and strokes; accumulation of fluid and worsen heart failure; cause or worsen hypertension and kidney failure.

DOSING: The recommended dose is 50-100 mg 2 to 4 times daily. The maximum daily dose is 300 mg. Flurbiprofen should be taken with food to reduce stomach upset.

DRUG INTERACTIONS: Flurbiprofen is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of the increased risk of bleeding. Patients taking lithium (Lithobid, Eskalith) can develop toxic blood levels of lithium because flurbiprofen may inhibit the elimination of lithium from the body by the kidney.

Side effects from methotrexate (Trexall, Rheumatrex) and cyclosporine also may be increased by flurbiprofen.

Flurbiprofen may reduce the effectiveness of medications that are used for treating high blood pressure because it causes or worsens high blood pressure. NSAIDs may diminish the blood pressure-lowering effects of angiotensin converting enzyme (ACE) inhibitors. Combining NSAIDs with angiotensin receptor blockers (for example, valsartan [Diovan], losartan [Cozaar], irbesartan [Avapro]) or angiotensin converting enzyme inhibitors (for example, enalapril [Vasotec], captopril [Captoen]) in patients who are elderly, volume-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible.

Medically Reviewed by a Doctor on 2/17/2015

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