fluphenazine (Permitil, Prolixin) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC AVAILABLE: Yes
PREPARATIONS: Oral elixir: 2.5 mg/5 ml. Oral solution: 5 mg/ml. Tablets: 1, 2.5, 5, and 10 mg.
STORAGE: Fluphenazine tablets, oral elixir, and oral solution should be stored between 20 C and 25 C (68 F and 77 F).
DOSING: The recommended starting dose of fluphenazine is 2.5 to 10 mg per day orally in divided doses, every 6 to 8 hours. Doses may be increased as needed and as tolerated to a maximum of 40 mg per day. Once symptoms are controlled, maintenance oral doses of 1 to 5 mg per day are recommended. Dose adjustment is based on individual response and side effects of the medication.
DRUG INTERACTIONS: Combining fluphenazine with medications such as procainamide (Pronestyl), sotalol (Betapace), amiodarone (Cordarone), and dofetilide (Tikosyn) that affect heart rate and rhythm can cause abnormal heart beats.
Antidepressants such as fluoxetine (Prozac), sertraline (Zoloft), amitriptyline (Elavil), and nortriptyline (Pamelor) can cause an abnormal heart rate and rhythm; ombining them with fluphenazine increases the risk of abnormal heart beats.
Fluphenazine should not be combined with other antipsychotics such as aripiprazole (Abilify) and risperidone (Risperdal) because such combinations can cause abnormal muscle contractions, difficulty breathing and swallowing, and neck spasms. Patients should seek medical help when experiencing such effects.
Medically Reviewed by a Doctor on 12/23/2014
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