Antidepressants such as fluoxetine (Prozac), sertraline (Zoloft), amitriptyline (Elavil), and nortriptyline (Pamelor) can cause an abnormal heart rate and rhythm; ombining them with fluphenazine increases the risk of abnormal heart beats.
Fluphenazine should not be combined with other antipsychotics such as aripiprazole (Abilify) and risperidone (Risperdal) because such combinations can cause abnormal muscle contractions, difficulty breathing and swallowing, and neck spasms. Patients should seek medical help when experiencing such effects.
Fluphenazine may increase lithium (Lithobid, Eskolith) levels in the body. Patients may experience increased side effects of lithium such as increased thirst, decreased heart rate, weakness, blurred vision, decreased concentration, and ringing in the ears.
Fluphenazine should be used with caution with medications that depress the central nervous system and cause sedation or drowsiness. Examples include alprazolam (Xanax), clonazepam (Klonopin), zolpidem (Ambien), codeine, morphine, and alcohol. Such combinations can cause excessive sedation, drowsiness, weakness, confusion, speech impairment, and in severe cases coma or death.
PREGNANCY: Safe and effective use of fluphenazine is not established in pregnant females; however, it should be avoided to prevent harm to the unborn.
NURSING MOTHERS: Fluphenazine enters breast milk; therefore, it should be avoided in females who are nursing.
REFERENCE: FDA Prescribing Information.
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