fluphenazine (Permitil, Prolixin)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Coping With Schizophrenia

Tardive dyskinesia (movement abnormalities of the face, arms, and legs) can result from fluphenazine treatment.

Neuroleptic malignant syndrome (NMS) which includes symptoms such as fever, muscle rigidity, altered mental status, irregular blood pressure, and irregular heart rate and rhythm can occur. These side effects can be severe so patients must seek medical help.

Elderly patients with dementia-related psychosis treated with antipsychotics are at an increased risk of death, and fluphenazine should not be used for treating patients with dementia related psychosis.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Oral elixir: 2.5 mg/5 ml. Oral solution: 5 mg/ml. Tablets: 1, 2.5, 5, and 10 mg.

STORAGE: Fluphenazine tablets, oral elixir, and oral solution should be stored between 20 C and 25 C (68 F and 77 F).

DOSING: The recommended starting dose of fluphenazine is 2.5 to 10 mg per day orally in divided doses, every 6 to 8 hours. Doses may be increased as needed and as tolerated to a maximum of 40 mg per day. Once symptoms are controlled, maintenance oral doses of 1 to 5 mg per day are recommended. Dose adjustment is based on individual response and side effects of the medication.

DRUG INTERACTIONS: Combining fluphenazine with medications such as procainamide (Pronestyl), sotalol (Betapace), amiodarone (Cordarone), and dofetilide (Tikosyn) that affect heart rate and rhythm can cause abnormal heart beats.

Medically Reviewed by a Doctor on 12/23/2014

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