fluphenazine (Permitil, Prolixin) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

The FDA approved fluphenazine in September 1959.

PRESCRIBED FOR: Fluphenazine is prescribed for the management of schizophrenia.

SIDE EFFECTS: Fluphenazine causes extrapyramidal side effects such as:

  • Abnormal muscle contractions
  • Difficulty breathing and swallowing
  • Neck spasms

Other side effects include:

Tardive dyskinesia (movement abnormalities of the face, arms, and legs) can result from fluphenazine treatment.

Neuroleptic malignant syndrome (NMS) which includes symptoms such as fever, muscle rigidity, altered mental status, irregular blood pressure, and irregular heart rate and rhythm can occur. These side effects can be severe so patients must seek medical help.

Elderly patients with dementia-related psychosis treated with antipsychotics are at an increased risk of death, and fluphenazine should not be used for treating patients with dementia related psychosis.

Medically Reviewed by a Doctor on 12/23/2014

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