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- What is fluphenazine-oral, and how does it work (mechanism of action)?
- What brand names are available for fluphenazine-oral?
- Is fluphenazine-oral available as a generic drug?
- Do I need a prescription for fluphenazine-oral?
- What are the side effects of fluphenazine-oral?
- What is the dosage for fluphenazine-oral?
- Which drugs or supplements interact with fluphenazine-oral?
- Is fluphenazine-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about fluphenazine-oral?
What is fluphenazine-oral, and how does it work (mechanism of action)?
Fluphenazine is an oral antipsychotic medication used for the management of schizophrenia. Fluphenazine is one of the older, first-generation piperazine phenothiazine antipsychotic medications. Examples of other phenothiazines include:
- prochlorperazine (Compazine, Compro, Procomp),
- chlorpromazine (Promapar, Thorazine),
- perphenazine, trifluoperazine (Stelazine), and
- thioridazine (Mellaril).
Although the exact mechanism of phenothiazine antipsychotics is unknown, scientists believe that they may work by blocking the action of dopamine in the brain. Dopamine is a neurotransmitter (chemical) that nerves use to communicate with one another. Phenothiazine antipsychotics are used when patients do not respond to other antipsychotics.
The FDA approved fluphenazine in September 1959.
What brand names are available for fluphenazine-oral?
Is fluphenazine-oral available as a generic drug?
Do I need a prescription for fluphenazine-oral?
What are the side effects of fluphenazine-oral?
Fluphenazine causes extrapyramidal side effects such as:
- Abnormal muscle contractions
- Difficulty breathing and swallowing
- Neck spasms
Other side effects include:
Tardive dyskinesia (movement abnormalities of the face, arms, and legs) can result from fluphenazine treatment.
Neuroleptic malignant syndrome (NMS) which includes symptoms such as fever, muscle rigidity, altered mental status, irregular blood pressure, and irregular heart rate and rhythm can occur. These side effects can be severe so patients must seek medical help.
Elderly patients with dementia-related psychosis treated with antipsychotics are at an increased risk of death, and fluphenazine should not be used for treating patients with dementia related psychosis.
Quick GuideSchizophrenia: Symptoms, Types, Causes, Treatment
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