fluphenazine (Permitil, Prolixin)

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GENERIC NAME: fluphenazine hydrochloride

BRAND NAME: Permitil, Prolixin

DRUG CLASS AND MECHANISM: Fluphenazine is an oral antipsychotic medication used for the management of schizophrenia. Fluphenazine is one of the older, first-generation piperazine phenothiazine antipsychotic medications. Examples of other phenothiazines include:

  • prochlorperazine (Compazine, Compro, Procomp),
  • chlorpromazine (Promapar, Thorazine),
  • perphenazine, trifluoperazine (Stelazine), and
  • thioridazine (Mellaril).

Although the exact mechanism of phenothiazine antipsychotics is unknown, scientists believe that they may work by blocking the action of dopamine in the brain. Dopamine is a neurotransmitter (chemical) that nerves use to communicate with one another. Phenothiazine antipsychotics are used when patients do not respond to other antipsychotics.

The FDA approved fluphenazine in September 1959.

PRESCRIBED FOR: Fluphenazine is prescribed for the management of schizophrenia.

SIDE EFFECTS: Fluphenazine causes extrapyramidal side effects such as:

  • Abnormal muscle contractions
  • Difficulty breathing and swallowing
  • Neck spasms

Other side effects include:

Medically Reviewed by a Doctor on 12/23/2014



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