fluphenazine (Permitil, Prolixin)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

GENERIC NAME: fluphenazine hydrochloride

BRAND NAME: Permitil, Prolixin

DRUG CLASS AND MECHANISM: Fluphenazine is an oral antipsychotic medication used for the management of schizophrenia. Fluphenazine is one of the older, first-generation piperazine phenothiazine antipsychotic medications. Examples of other phenothiazines include:

Although the exact mechanism of phenothiazine antipsychotics is unknown, scientists believe that they may work by blocking the action of dopamine in the brain. Dopamine is a neurotransmitter (chemical) that nerves use to communicate with one another. Phenothiazine antipsychotics are used when patients do not respond to other antipsychotics.

The FDA approved fluphenazine in September 1959.

PRESCRIBED FOR: Fluphenazine is prescribed for the management of schizophrenia.

SIDE EFFECTS: Fluphenazine causes extrapyramidal side effects such as:

  • Abnormal muscle contractions
  • Difficulty breathing and swallowing
  • Neck spasms

Other side effects include:

Medically Reviewed by a Doctor on 12/23/2014

Quick GuideSchizophrenia: Symptoms, Types, Causes, and Treatment

Schizophrenia: Symptoms, Types, Causes, and Treatment
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