fluoxetine, Prozac, Sarafem, Prozac Weekly (cont.)

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PREPARATIONS: Capsules: 10, 20 and 40 mg. Capsules (delayed release): 90 mg. Tablets: 10, 20 and 60 mg. Oral suspension: 20 mg/5ml

STORAGE: Fluoxetine should be stored at room temperature 15 C to 30 C (59 F to 86 F).

PRESCRIBED FOR: Fluoxetine is used for treating depression, bulimia, obsessive-compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder (PMDD). It also is used in combination with olanzapine (Zyprexa) for treatment of resistant depression and treatment of depression associated with bipolar disorder.

DOSING: Depression in adults is treated with 20-80 mg of fluoxetine daily. The recommended dose for treating depression in children is 10-20 mg daily. After 13 weeks of daily administration, 90 mg once weekly may be effective in some patients.

Bulimia is treated with 60 mg of fluoxetine daily. Long-term treatment for up to 52 weeks has been shown to be beneficial in maintaining remission.

Obsessive-compulsive disorder in adults and children is treated with 20-80 mg daily and panic disorder is managed with 10-60 mg daily.

The recommended regimen for premenstrual dysphoric disorder is 20 mg (maximum dose 80 mg) administered every day of the menstrual cycle or daily for 14 days prior to the onset of menstruation through the first day of menses.

The recommended treatment for treatment resistant depression is 20-50 mg of fluoxetine and 5-20 mg olanzapine once daily in the evening while the recommended treatment for depression associated with bipolar disorder is 20-50 mg fluoxetine and 5-12.5 mg olanzapine once daily in the evening.

DRUG INTERACTIONS: Fluoxetine should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants (for example, isocarboxazid [Marplan], phenelzine [Nardil], tranylcypromine [Parnate], selegiline [Eldepryl], and procarbazine [Matulane]) or other drugs that inhibit monoamine oxidase such as linezolid [Zyvox] and intravenous methylene blue. Such combinations may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. Fluoxetine should not be administered for at least 14 days after stopping MAOIs. Because fluoxetine is active in the body for several weeks, MAOIs should not be administered for at least 5 weeks (possibly longer after long term use of fluoxetine or if large doses were used) after fluoxetine has been stopped. Similar reactions occur when fluoxetine is combined with other drugs, for example, tryptophan, St. John's wort, meperidine (Demerol), lithium (Lithobid, Eskalith), triptans (for example, sumatriptan [Imitrex)]), and tramadol (Ultram) that increase serotonin in the brain.

Medically Reviewed by a Doctor on 11/4/2014

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