fluoxetine, Prozac, Sarafem, Prozac Weekly

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    Jay W. Marks, MD

    Jay W. Marks, MD

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Understanding Depression Slideshow

What is fluoxetine, and how does it work (mechanism of action)?

Fluoxetine is an oral drug that is used primarily for treating depression. It is in a class of drugs called selective serotonin reuptake inhibitors (SSRIs), a class that includes citalopram (Celexa), paroxetine (Paxil) and sertraline (Zoloft). Fluoxetine affects neurotransmitters, the chemicals that nerves within the brain use to communicate with each other. Neurotransmitters are manufactured and released by nerves and then travel and attach to nearby nerves. Thus, neurotransmitters can be thought of as the communication system of the brain. Serotonin is one neurotransmitter that is released by nerves in the brain. The serotonin either travels across the space between nerves and attaches to receptors on the surface of nearby nerves or it attaches to receptors on the surface of the nerve that produced it, to be taken up by the nerve and released again (a process referred to as re-uptake). Many experts believe that an imbalance among neurotransmitters is the cause of depression. Fluoxetine works by preventing the reuptake of one neurotransmitter, serotonin, by nerve cells after it has been released. Since uptake is an important mechanism for removing released neurotransmitters and terminating their actions on adjacent nerves, the reduced uptake caused by fluoxetine increases free serotonin that stimulates nerve cells in the brain. The FDA approved Fluoxetine in December 1987.

What brand names are available for fluoxetine?

Prozac, Sarafem, Prozac Weekly

Is fluoxetine available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for fluoxetine?

Yes

What are the side effects of fluoxetine?

Fluoxetine, as with most antidepressants, can cause nausea, headaches, anxiety, insomnia, drowsiness, and loss of appetite. Fluoxetine has been implicated in serious skin rashes and vasculitis (inflammation of small blood vessels). Increased blood pressure can occur, and blood pressure should be monitored. Seizures have been reported as has sexual dysfunction. Some patients may experience withdrawal reactions upon stopping fluoxetine. Symptoms of withdrawal include anxiety, nausea, nervousness, and insomnia. The dose of fluoxetine should be gradually reduced when therapy is discontinued. Fluoxetine and other antidepressants have been associated with angle closure attacks in people with narrow angle glaucoma.

Antidepressants increased the risk of suicidal thinking and behavior in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of fluoxetine or any other antidepressant in a child or adolescent must balance this risk of suicide with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.

Quick GuidePhysical Symptoms of Depression in Pictures

Physical Symptoms of Depression in Pictures

What is the dosage for fluoxetine?

: Depression in adults is treated with 20-80 mg of fluoxetine daily. The recommended dose for treating depression in children is 10-20 mg daily. After 13 weeks of daily administration, 90 mg once weekly may be effective in some patients.

Is fluoxetine safe to take if I'm pregnant or breastfeeding?

Fluoxetine is excreted in breast milk. Therefore, use of fluoxetine while nursing is not recommended.

What else should I know about fluoxetine?

What preparations of fluoxetine are available?

Capsules: 10, 20 and 40 mg. Capsules (delayed release): 90 mg. Tablets: 10, 20 and 60 mg. Oral suspension: 20 mg/5ml

How should I keep fluoxetine stored?

Fluoxetine should be stored at room temperature 15 C to 30 C (59 F to 86 F).

Reference: FDA Prescribing Information

Last Editorial Review: 11/4/2014

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See more info: fluoxetine on RxList
Reviewed on 11/4/2014
References
Reference: FDA Prescribing Information

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