fludrocortisone (Florinef)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

What is the dosage for fludrocortisone-oral?

  • Addison's disease: The usual recommended dose is 0.1 mg by mouth once daily without regard to food. Dose should be reduced to 0.05 mg daily if hypertension develops. Maintenance dosage range is 0.1 to 0.2 mg 3 times weekly. Fludrocortisone is preferably administered with cortisone (10 to 37.5 mg daily) or hydrocortisone (10 to 30 mg daily).
  • Salt losing adrenogenital syndrome: The recommended dose is 0.1 to 0.2 mg daily.

Which drugs or supplements interact with fludrocortisone-oral?

: Antacids and bile acid sequestrants (for example, cholestyramine [Questran, Questran Light], colestipol [Colestid], and colesevelam [Welchol]) may decrease the absorption of oral corticosteroids.

Oral corticosteroids may decrease the effectiveness of diabetes medications.

Medications that may decrease blood levels of corticosteroids include barbiturates, isoniazid (Nydrazid, Laniazid, INH), mitotane (Lysodren), rifampin (Rifadin, Rifadin IV), aminoglutethimide (Cytadren), primidone (Mysoline), and others.

Medications that may increase blood levels of corticosteroids include aprepitant (Emend), strong CYP3A4 inhibitors, estrogen derivatives, mifepristone (Mifeprex), and others.

Corticosteroids may increase the risk of adverse effects associated with live vaccine administration.

Medically Reviewed by a Doctor on 9/29/2015

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