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fluconazole 150 mg - oral, Diflucan (cont.)

PRECAUTIONS: Before taking fluconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungal drugs (e.g., ketoconazole, itraconazole); or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease.Fluconazole may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that require immediate medical attention. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may affect the heart rhythm (see also Drug Interactions section). Before using fluconazole, tell your doctor or pharmacist if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using fluconazole safely.Although uncommon, this drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.Because kidney function can decrease with age, use caution in the elderly as they may be more sensitive to the effects of this medicationThis medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.Fluconazole passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used with the following medication because a very serious interaction may occur: cisapride.If you are currently using this medication, tell your doctor or pharmacist before starting fluconazole.Many drugs besides fluconazole may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others. Therefore, before using fluconazole, report all medications you are currently using to your doctor or pharmacist.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal drugs you may use, especially of: rifamycins (e.g., rifabutin, rifampin), warfarin.Fluconazole can slow down the removal of other medications from your body, thereby affecting how they work. These affected drugs include amitriptyline, certain drugs that affect the immune system (e.g., cyclosporine, tacrolimus, sirolimus), certain calcium channel blockers (e.g., felodipine, nifedipine, nisoldipine), eplerenone, certain "statin" cholesterol medications (atorvastatin, fluvastatin, lovastatin, simvastatin), celecoxib, certain drugs to treat diabetes (glipizide, glyburide, tolbutamide), certain benzodiazepines (e.g., alprazolam, midazolam, triazolam), certain anti-seizure drugs (carbamazepine, phenytoin), zidovudine. This is not a complete list.This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.



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