fluconazole, Diflucan (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Rifampin (Rifadin, Rimactane, Rifadin, Rifater, Rifamate) reduces the blood concentration of oral fluconazole, probably by increasing the elimination of fluconazole in the liver; therefore, reducing the effectiveness of fluconazole.

Fluconazole may increase the concentration of warfarin (Coumadin) in blood by reducing the elimination of warfarin. Therefore, the effect of warfarin may increase, leading to an increased tendency to bleed. Fluconazole also increases the concentration in the blood of phenytoin (Dilantin), cyclosporine, zidovudine (Retrovir), saquinavir (Invirase), (theophylline (Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin), tolbutamide, glyburide (Micronase, Diabeta, Glynase), glipizide, triazolam (Glucotrol), midazolam (Versed), celecoxib (Celebrex), fentanyl (Sublimaze), atorvastatin (Lipitor), simvastatin (Zocor), and lovastatin (Mevacor). As a result, the risk of side effects from these drugs may increase.

Medically Reviewed by a Doctor on 12/31/2014

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