fluconazole, Diflucan (cont.)

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DOSING: The usual adult dose is 50-400 mg daily depending on the type of infection. Although symptoms of oral Candida infections may subside in a few days, treatment is continued for 2 weeks. Esophageal Candida infections are treated for 3 weeks or longer. Treatment of cryptococcal meningitis may last for 10-12 weeks after cerebrospinal fluid cultures become negative.

DRUG INTERACTIONS: Hydrochlorothiazide increases the blood concentration of fluconazole by 40%. However, dosage modification is not recommended when both drugs are combined.

Rifampin (Rifadin, Rimactane, Rifadin, Rifater, Rifamate) reduces the blood concentration of oral fluconazole, probably by increasing the elimination of fluconazole in the liver; therefore, reducing the effectiveness of fluconazole.

Fluconazole may increase the concentration of warfarin (Coumadin) in blood by reducing the elimination of warfarin. Therefore, the effect of warfarin may increase, leading to an increased tendency to bleed. Fluconazole also increases the concentration in the blood of phenytoin (Dilantin), cyclosporine, zidovudine (Retrovir), saquinavir (Invirase), (theophylline (Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin), tolbutamide, glyburide (Micronase, Diabeta, Glynase), glipizide, triazolam (Glucotrol), midazolam (Versed), celecoxib (Celebrex), fentanyl (Sublimaze), atorvastatin (Lipitor), simvastatin (Zocor), and lovastatin (Mevacor). As a result, the risk of side effects from these drugs may increase.

Medically Reviewed by a Doctor on 4/4/2013


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