fluconazole, Diflucan (cont.)

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Medical and Pharmacy Editor:

SIDE EFFECTS: Common side effects of fluconazole are:

Other important side effects include:

Rarely, serious allergic reactions, including angioedema (swelling of tissues), may also occur. Liver dysfunction (jaundice, hepatitis) and abnormal heart beats have been associated with fluconazole.



PREPARATIONS: Tablets: 50, 100, 150 and 200 mg. Oral Suspension: 10 mg/ml and 40 mg/ml. Injection: 2 mg/ml

STORAGE: Tablets and dry powder should be stored below 86 F (30 C). Injection and reconstituted suspension should be stored between 5 C to 30 C (41 F to 86 F). Unused portions of the reconstituted suspension should be protected from freezing and discarded after 2 weeks.

DOSING: The usual adult dose is 50-400 mg daily depending on the type of infection. Although symptoms of oral Candida infections may subside in a few days, treatment is continued for 2 weeks. Esophageal Candida infections are treated for 3 weeks or longer. Treatment of cryptococcal meningitis may last for 10-12 weeks after cerebrospinal fluid cultures become negative.

DRUG INTERACTIONS: Hydrochlorothiazide increases the blood concentration of fluconazole by 40%. However, dosage modification is not recommended when both drugs are combined.

Rifampin (Rifadin, Rimactane, Rifadin, Rifater, Rifamate) reduces the blood concentration of oral fluconazole, probably by increasing the elimination of fluconazole in the liver; therefore, reducing the effectiveness of fluconazole.

Medically Reviewed by a Doctor on 12/31/2014

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