fluconazole, Diflucan (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

SIDE EFFECTS: Common side effects of fluconazole are:

Other important side effects include:

Rarely, serious allergic reactions, including angioedema (swelling of tissues), may also occur. Liver dysfunction (jaundice, hepatitis) and abnormal heart beats have been associated with fluconazole.



PREPARATIONS: Tablets: 50, 100, 150 and 200 mg. Oral Suspension: 10 mg/ml and 40 mg/ml. Injection: 2 mg/ml

STORAGE: Tablets and dry powder should be stored below 86 F (30 C). Injection and reconstituted suspension should be stored between 5 C to 30 C (41 F to 86 F). Unused portions of the reconstituted suspension should be protected from freezing and discarded after 2 weeks.

DOSING: The usual adult dose is 50-400 mg daily depending on the type of infection. Although symptoms of oral Candida infections may subside in a few days, treatment is continued for 2 weeks. Esophageal Candida infections are treated for 3 weeks or longer. Treatment of cryptococcal meningitis may last for 10-12 weeks after cerebrospinal fluid cultures become negative.

DRUG INTERACTIONS: Hydrochlorothiazide increases the blood concentration of fluconazole by 40%. However, dosage modification is not recommended when both drugs are combined.

Medically Reviewed by a Doctor on 12/31/2014

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