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fluconazole - injection, Diflucan (cont.)

PRECAUTIONS: Before using fluconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungal drugs (e.g., itraconazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease.Fluconazole may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using fluconazole, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using fluconazole safely.Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above).During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby if used in high doses daily during the first 3 months of pregnancy. Discuss the risks and benefits with your doctor.This drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: cisapride, rifamycins (e.g., rifabutin, rifampin), warfarin.Many other drugs besides fluconazole may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, quinidine, sotalol, procainamide, macrolide antibiotics (such as erythromycin), among others. Therefore, before using fluconazole, report all medications you are currently using to your doctor or pharmacist.Fluconazole can slow down the removal of other medications from your body, thereby affecting how they work. These affected drugs include amitriptyline, certain drugs that affect the immune system (e.g., cyclosporine, tacrolimus, sirolimus), certain calcium channel blockers (e.g., felodipine, nifedipine, nisoldipine), eplerenone, certain "statin" cholesterol medications (atorvastatin, fluvastatin, lovastatin, simvastatin), celecoxib, certain benzodiazepines (e.g., alprazolam, midazolam, triazolam), certain anti-seizure drugs (carbamazepine, phenytoin), zidovudine. This is not a complete list.



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