Flakka

  • Medical Author:
    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.

  • Medical Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

Prescription Drug Abuse Statistics

What is Flakka? What are the signs and symptoms of Flakka abuse?

A new synthetic street drug called "Flakka" is making the news. Since September 2014, hospitals, doctors (myself included), police, and fire rescue crews in Florida have seen patients with symptoms and signs that include bizarre behavior, agitation, paranoia, and delusions of superhuman strength. Recent reported cases include an agitated man running naked through traffic, a delusional drug addict who attempted to perform a sex act on a tree and then resisted arrest, and a paranoid man trying to break into a police station to seek safety. These bizarre and dangerous behaviors are directly due to the side effects of this new street drug, Flakka.

Flakka vs. bath salts

Word on the street is that Flakka (also called gravel or flocka) is a combination of heroin and crack, or heroin and methamphetamines, but in reality, Flakka is just a newer-generation version of bath salts. Bath salts, in general, are synthetic psychoactive drugs made in large quantities in foreign drug labs. These drugs are all related to a broader group of chemical compounds known as cathinones. Each time one type of bath salt is made illegal, the drug labs change the chemical structure slightly and a new drug that is technically not illegal is created. In the case of Flakka, the new chemical is called alpha-pyrrolidinopentiophenone or alpha-PVP. Drug users take Flakka to get a feeling of euphoria, a heightened sense of awareness, stimulation, and energy.

What are the side effects of Flakka?

Flakka has many bad side effects, mostly including changes in behavior or mood. Even slight overdoses of Flakka can cause extreme agitation, jerking muscle movements, delirious thoughts, and often profound paranoia. In some of the documented delusions, individuals' experiences are of a typical paranoia, where the drug users feel they are being chased by a large group of people trying to kill them. These patients are a threat to themselves, the people around them, and the first responders (police, EMS) who are there to help them. It is common to hear reports that it takes multiple people to restrain and sedate these patients. Rescue crews and emergency department staff need to give sedatives to these patients to calm them and make them safe.

Paranoia is a symptom of Flakka abuse.

Flakka Symptom

Paranoia

Paranoia refers to the perception or suspicion that others have hostile or aggressive motives in interacting with them (for example, "they are out to get me"), when in fact there is no reason for these suspicions. People experiencing paranoia believe that others are persecuting them and have delusional ideas about themselves as central figures in scenarios that in reality have little relevance to them. They may mistrust others and remain often in a state of suspicion. Intoxication from alcohol or drug abuse may also lead to feelings of paranoia.

What are the complications of Flakka use?

Some complications of Flakka abuse can happen while the drug user is acutely agitated, if they were to harm themselves or others; however, medically, the severe consequences of the agitation caused by the drug appear later. Patients who are agitated can go into a state called "excited delirium," which is a medical emergency. In the excited delirium state, restrained patients struggle to free themselves, scream, flail, and can even have seizures. This struggling causes a high core body temperature called hyperthermia. The combination of a high body temperature and the extreme muscle overactivity can cause other metabolic problems to happen in the body. Muscle tissue begins to break down, releasing proteins and other cellular products into the bloodstream, in a process called rhabdomyolysis. The extreme struggling can also cause dehydration. The end result of the cellular products and proteins released during rhabdomyolysis and dehydration can impair the filtering function of the kidneys, leading to renal failure and death. In addition, such agitation may trigger Taser use or other methods that have the potential to harm the individual when law enforcement personnel have to intervene.

So far, individuals with Flakka overdose have been isolated to a few geographic regions of the country, but law enforcement and DEA officials say we may be seeing the beginning of a major drug-based epidemic with a concurrent social problem.

Medically reviewed by Marina Katz, MD; American Board of Psychiatry & Neurology

REFERENCES:

"'Bath Salts' Intoxication." N Engl J Med 365 Sept. 8, 2011: 967-968. <http://www.nejm.org/doi/full/10.1056/NEJMc1107097>.

Kaizaki, A., S. Tanaka, and S. Numazawa. "New recreational drug 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (alpha-PVP) activates central nervous system via dopaminergic neuron." J Toxicol Sci 39.1 Feb. 2014: 1-6. <http://www.ncbi.nlm.nih.gov/pubmed/24418703>.

"The Science of Alpha-PVP ('Gravel'), a Second-Generation Bath Salt." The Poison Review. Mar. 14, 2014. <http://www.thepoisonreview.com/2014/03/14/the-science-of-alpha-pvp-gravel-a-second-generation-bath-salt/>.

"Violent, Impaired and/or Excited Delirium (ExDS) Patient." Greater Broward EMS Medical Director's Association. <http://www.gbemda.org/adult-2/2-5-adult-neurologic-emergencies/2-5-2-violent-andor-impaired-patient>.

Last Editorial Review: 12/1/2016

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Reviewed on 12/1/2016
References
Medically reviewed by Marina Katz, MD; American Board of Psychiatry & Neurology

REFERENCES:

"'Bath Salts' Intoxication." N Engl J Med 365 Sept. 8, 2011: 967-968. <http://www.nejm.org/doi/full/10.1056/NEJMc1107097>.

Kaizaki, A., S. Tanaka, and S. Numazawa. "New recreational drug 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (alpha-PVP) activates central nervous system via dopaminergic neuron." J Toxicol Sci 39.1 Feb. 2014: 1-6. <http://www.ncbi.nlm.nih.gov/pubmed/24418703>.

"The Science of Alpha-PVP ('Gravel'), a Second-Generation Bath Salt." The Poison Review. Mar. 14, 2014. <http://www.thepoisonreview.com/2014/03/14/the-science-of-alpha-pvp-gravel-a-second-generation-bath-salt/>.

"Violent, Impaired and/or Excited Delirium (ExDS) Patient." Greater Broward EMS Medical Director's Association. <http://www.gbemda.org/adult-2/2-5-adult-neurologic-emergencies/2-5-2-violent-andor-impaired-patient>.

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