GENERIC NAME: fingolimod
BRAND NAME: Gilenya
DRUG CLASS AND MECHANISM: Fingolimod is an oral medication used for treating multiple sclerosis (MS). Its mechanism of action is unknown, although it may work by reducing the number of circulating lymphocytes (a type of white blood cell), leading to reduced migration of white blood cells into the central nervous system. White blood cells cause inflammation and destruction of nerves in patients with MS. Fingolimod does not cure MS. It decreases the number of MS flares and slows down the development of physical disability caused by MS. The FDA approved fingolimod in September 2010.
PRESCRIBED FOR: Fingolimod is used for reducing the frequency of relapses and for delaying the occurrence of physical disability in patients with relapsing forms of multiple sclerosis.
SIDE EFFECTS: The most common side effects are:
Fingolimod may decrease heart rate, especially after the first dose. Patients should be observed for signs and symptoms of low heart rate for 6 hours after the first dose. Fingolimod may increase the risk of infections. Signs and symptoms of infection should be monitored during treatment and for two months after discontinuation of treatment. Fingolimod should not be administered to patients who have an infection. Fingolimod may cause inflammation of the eye (uveitis) and other eye problems. Therefore, visual acuity should be checked prior to starting therapy, 3 to 4 months after initiation of therapy, and during routine patient evaluation. Fingolimod has also been associated with difficulty breathing. Fingolimod reduces the white blood cell count, and this effect may last for 2 months after treatment is discontinued.
Quick GuideMultiple Sclerosis Pictures Slideshow: Causes, Symptoms and Treatment
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.