fingolimod, Gilenya

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GENERIC NAME: fingolimod

BRAND NAME: Gilenya

DRUG CLASS AND MECHANISM: Fingolimod is an oral medication used for treating multiple sclerosis (MS). Its mechanism of action is unknown, although it may work by reducing the number of circulating lymphocytes (a type of white blood cell), leading to reduced migration of white blood cells into the central nervous system. White blood cells cause inflammation and destruction of nerves in patients with MS. Fingolimod does not cure MS. It decreases the number of MS flares and slows down the development of physical disability caused by MS. The FDA approved fingolimod in September 2010.

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

PREPARATIONS: Capsules: 0.5 mg.

STORAGE: Fingolimod should be stored at room temperature, 15-30 C (59-86 F).

PRESCRIBED FOR: Fingolimod is used for reducing the frequency of relapses and for delaying the occurrence of physical disability in patients with relapsing forms of multiple sclerosis.

DOSING: The recommended dose is 0.5 mg orally once daily, with or without food. Doses higher than 0.5 mg cause more adverse reactions without providing additional benefit.

DRUG INTERACTIONS: The blood levels of fingolimod are increased when combined with ketoconazole (Nizoral, Extina, Xolegel, Kuric). This may increase the incidence of side effects.




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