DRUG INTERACTIONS: Allegra-D should not be taken with monoamine oxidase (MAO) inhibitor drugs such as phenelzine (Nardil) and tranylcypromine (Parnate) because combining pseudoephedrine with MAO inhibitors can lead to dangerous increases in blood pressure and other serious side effects. Aluminum containing antacids (for example, Maalox) reduces the absorption of fexofenadine. Therefore, aluminum containing antacids and fexofenadine should not be administered together. Fruit juices (apple, orange, grapefruit) may reduce the absorption of fexofenadine, andexofenadine should only be administered with water.
PREGNANCY: Pseudoephedrine causes birth defects in some animal species. Additionally, there have been associations between first trimester exposure to drugs related to pseudoephedrine and fetal malformations, though the malformations have been primarily minor. Thus, Allegra-D should be used in pregnancy only if the physician feels that the potential benefit outweighs the risks. Fexofenadine has not been adequately studied in pregnant women.
NURSING MOTHERS: Pseudoephedrine is secreted in breast milk. The American Academy of Pediatrics considers pseudoephedrine to be compatible with nursing. Fexofenadine has not been adequately studied in women who are breastfeeding.
Medically reviewed by Eni Williams, PharmD
Reference: FDA Prescribing Information
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