fentanyl transdermal patch, Duragesic

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GENERIC NAME: fentanyl transdermal patch

BRAND NAME: Duragesic

DRUG CLASS AND MECHANISM: Fentanyl is a potent synthetic (man-made) narcotic. A 100 µg dose of fentanyl is approximately equal to 10 mg of morphine. Fentanyl stimulates receptors on nerves in the brain to increase the threshold to pain (the amount of discomfort that a person must feel in order to be perceived as painful) and reduce the perception of pain (the perceived importance of the pain). Fentanyl is available in transdermal (for application to the skin), transmucosal (for application to mucus membranes) and parenteral (injectable) forms. When applied to the skin of the upper torso, fentanyl is well absorbed. The amount of fentanyl in the blood increases gradually after topical application, reaching a peak after 12-24 hours. Once this concentration is achieved, blood concentrations remain constant over the 72 hours that the patch is worn. After removal of the patch, blood concentrations of fentanyl decrease slowly due to ongoing absorption of fentanyl remaining on the skin. Fentanyl was originally approved by the FDA for injection in 1968 and was approved as a patch in August 1990.

PRESCRIBED FOR: The fentanyl transdermal system is used for patients with severe chronic pain, for example, cancer pain.

SIDE EFFECTS: Physical dependence occurs commonly during therapy with opiate agonists such as fentanyl. Abruptly stopping the drug in patients can precipitate a withdrawal reaction. Symptoms of withdrawal include:

Medically Reviewed by a Doctor on 6/8/2015



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