The recommended adult dose for mild to moderate pain is 200 mg every 4-6 hours.
Fenoprofen should be administered with meals in order to avoid stomach upset.
The safety and effectiveness of this drug in patients under age 18 has not been examined.
DRUG INTERACTIONS: Fenoprofen is associated with several suspected or probable interactions that affect the action of other drugs. The following examples are the most commonly suspected interactions.
- Fenoprofen may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.
- Fenoprofen may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation of blood pressure.
- When NSAIDs are used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because their elimination from the body is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.
- Individuals taking oral blood thinners or anticoagulants, for example, warfarin, (Coumadin), should avoid fenoprofen because fenoprofen also thins the blood, and excessive blood thinning may lead to bleeding.
- Persons who have more than three alcoholic beverages per day are at increased risk of developing stomach ulcers when taking fenoprofen or other NSAIDs.
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