fenoprofen, Nalfon

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GENERIC NAME: fenoprofen

BRAND NAME: Nalfon 200

DRUG CLASS AND MECHANISM: Fenoprofen is a nonsteroidal antiinflammatory drug (NSAID) that is effective for treating the fever, pain, and swelling caused by inflammation. Fenoprofen belongs to a class of drugs called nonsteroidal antiinflammatory drugs (NSAIDs). Other members of the NSAID class of drugs include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen), naproxen (Aleve) and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, chemicals that are responsible for the pain, fever, and swelling of inflammation. Fenoprofen blocks the enzymes that make prostaglandins (cyclooxygenases), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, swelling, pain and fever are reduced. Fenoprofen was approved by the FDA in March 1976.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Capsule: 200 mg; Tablet: 600 mg

STORAGE: Fenoprofen should be stored at room temperature, 20- 25 C (68-77 F), in a sealed container to avoid moisture.

PRESCRIBED FOR: Fenoprofen is used for the treatment of inflammation and pain due to rheumatoid arthritis and osteoarthritis. Fenoprofen also is used for the relief of mild to moderate pain, such as menstrual cramps, tendinitis, and bursitis.

DOSING: The recommended adult dose for mild to moderate pain is 200 mg every 4-6 hours. Rheumatoid arthritis and osteoarthritis are treated with 600 mg 3-4 times daily. The maximum daily dose is 3200 mg daily. Fenoprofen should be administered with meals in order to avoid stomach upset.

DRUG INTERACTIONS: Fenoprofen is associated with several suspected or probable interactions that affect the action of other drugs. The following examples are the most commonly suspected interactions.

Fenoprofen may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.

Fenoprofen may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation of blood pressure.

When NSAIDs are used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because their elimination from the body is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.

Individuals taking oral blood thinners or anticoagulants, for example, warfarin, (Coumadin), should avoid fenoprofen because fenoprofen also thins the blood, and excessive blood thinning may lead to bleeding.

Persons who have more than three alcoholic beverages per day are at increased risk of developing stomach ulcers when taking fenoprofen or other NSAIDs.

PREGNANCY: There are no adequate studies of fenoprofen in pregnant women. Therefore, fenoprofen is not recommended during pregnancy.




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