fenofibrate (Antara, Fenoglide, Fibricor, Lipofen, Lofibra, Tricor, Triglide, Trilipix)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Is fenofibrate safe to take during pregnancy or while breastfeeding?

Fenofibrate is classified as pregnancy category C. Use of fenofibrate in pregnant females has not been adequately evaluated. Fenofibrate should be avoided during pregnancy unless the benefits justify the potential risk to the fetus.

Fenofibrate should not be used in nursing mothers; however, it is unknown whether fenofibrate is excreted into breast milk.

What else should I know about fenofibrate?

What preparations of fenofibrate are available?
  • Oral capsules: 50 and 150 mg fenofibrate; 50 and 150 mg Lipofen
  • Oral tablets: 48, 54, 145, and 160 mg fenofibrate; 40 mg Fenoglide; 54 and 160 mg Lofibra; 48 and 145 mg Tricor; 50 and 160 mg Triglide
  • Micronized oral capsules: 30 and 90 mg Antara; 43, 67,130, 134, and 200 mg fenofibrate; 67, 134, and 200 mg Lofibra
How should I keep fenofibrate stored?

Fenofibrate products should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).

How does fenofibrate work?

Fenofibrate is a prodrug, which means that it must be converted to another chemical (fenofibric acid) in the body before it can work.

Fenofibric acid increases the activity of lipoprotein lipase, an enzyme that breaks down triglycerides, a type of fat in the blood. It also affects production, transportation, and storage of triglycerides. Overall benefits of fenofibrate use include a 30%-60% decrease in total blood triglycerides, a modest increase in high density lipoprotein cholesterol (HDL-C, commonly known as "good" cholesterol), and a decrease in low density lipoprotein cholesterol (LDL-C, commonly known as "bad" cholesterol) and total cholesterol.

Fenofibrate products are available in multiple strengths and dosage forms. Fenofibrate formulations are not bioequivalent and are not interchangeable except for generic equivalents.

When was fenofibrate approved by the FDA?

Fenofibrate was approved by the FDA in February 1998.

Medically reviewed by Eni Williams, PharmD, PhD

REFERENCES:

FDA Prescribing Informaiton.

UpToDate. Lipid lowering with fibric acid derivatives.

Medically Reviewed by a Doctor on 10/31/2016

Quick GuideLower Your Cholesterol, Save Your Heart

Lower Your Cholesterol, Save Your Heart
FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

RxList Logo

Need help identifying pills and medications?

Use the pill identifier tool on RxList.

Subscribe to MedicineNet's Heart Health Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Health Solutions From Our Sponsors