fenofibrate (Antara, Fenoglide, Fibricor, Lipofen, Lofibra, Tricor, Triglide, Trilipix) (cont.)

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Medical and Pharmacy Editor:

STORAGE: Fenofibrate products should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).

PRESCRIBED FOR: Fenofibrate is used with dietary modifications for the treatment of lipid disorders. It helps reduce levels of LDL-C, total cholesterol, triglycerides, and apolipoprotein B, and increase HDL-C. It is prescribed to patients with primary hypercholesterolemia or mixed dyslipidemia, and hypertriglyceridemia.

DOSING:

Hypertriglyceridemia

  • Antara: 43-130 mg orally once daily
  • Fenoglide: 40-120 mg orally once daily
  • Fibricor: 35-105 mg orally once daily
  • Lipofen: 50-150 mg orally once daily
  • Lofibra: 67-200 mg orally once daily
  • Tricor: 48-145 mg orally once daily
  • Triglide: 50-160 mg orally once daily
  • Triliprix: 45-135 mg orally once daily

Hypercholesterolemia or mixed hyperlipidemia

  • Antara: 130 mg orally once daily
  • Fenoglide: 120 mg orally once daily
  • Fibricor: 105 mg orally once daily
  • Lipofen: 150 mg orally once daily
  • Lofibra: 160 mg orally once daily
  • Tricor: 145 mg orally once daily
  • Triglide: 160 mg orally once daily
  • Trilipix: 135 mg orally once daily

DRUG INTERACTIONS: Bile acid sequestrants (colestipol [Colestid], cholestyramine [Questran, Questran Light]) may decrease the absorption of fibric acid and reduce their effectiveness.

Fibric acid derivatives may increase the adverse effects of colchicine (Colcrys) on muscle tissue.

Cyclosporine may increase the toxic effects of fibric acid derivatives on the kidney while fibric acid derivatives may decrease blood levels of cyclosporine.

Fenofibrate and its derivatives may increase the adverse effects associated with ezetimibe (Zetia), HMG-CoA reductase inhibitors (statins), and sulfonlyureas. Fibric acid derivatives may increase the anticoagulation (blood-thinning) benefits of warfarin (Coumadin).

Medically Reviewed by a Doctor on 11/11/2014


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