GENERIC NAME: fenofibrate
BRAND NAME: Antara, Fenoglide, Fibricor, Lipofen, Lofibra, Tricor, Triglide, Trilipix
DRUG CLASS AND MECHANISM: Fenofibrate is a derivative of fibric acid that is used to treat lipid disorders. It is a prodrug, which means that it must be converted to another chemical (fenofibric acid) in the body before it can work.
Fenofibric acid increases the activity of lipoprotein lipase, an enzyme that breaks down triglycerides, a type of fat in the blood. It also affects production, transportation, and storage of triglycerides. Overall benefits of fenofibrate use include a 30%-60% decrease in total blood triglycerides, a modest increase in high density lipoprotein cholesterol (HDL-C, commonly known as "good" cholesterol), and a decrease in low density lipoprotein cholesterol (LDL-C, commonly known as "bad" cholesterol) and total cholesterol.
Fenofibrate products are available in multiple strengths and dosage forms. Fenofibrate formulations are not bioequivalent and are not interchangeable except for generic equivalents. Fenofibrate was approved by the FDA in February 1998.
GENERIC AVAILABLE: Yes
- Oral capsules: 50 and 150 mg fenofibrate; 50 and 150 mg Lipofen
- Oral tablets: 48, 54, 145, and 160 mg fenofibrate; 40 mg Fenoglide; 54 and 160 mg Lofibra; 48 and 145 mg Tricor; 50 and 160 mg Triglide
- Micronized oral capsules: 30 and 90 mg Antara; 43, 67,130, 134, and 200 mg fenofibrate; 67, 134, and 200 mg Lofibra
STORAGE: Fenofibrate products should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).
PRESCRIBED FOR: Fenofibrate is used with dietary modifications for the treatment of lipid disorders. It helps reduce levels of LDL-C, total cholesterol, triglycerides, and apolipoprotein B, and increase HDL-C. It is prescribed to patients with primary hypercholesterolemia or mixed dyslipidemia, and hypertriglyceridemia.
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