fenofibrate (Antara, Fenoglide, Fibricor, Lipofen, Lofibra, Tricor, Triglide, Trilipix)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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GENERIC NAME: fenofibrate

BRAND NAME: Antara, Fenoglide, Fibricor, Lipofen, Lofibra, Tricor, Triglide, Trilipix

DRUG CLASS AND MECHANISM: Fenofibrate is a derivative of fibric acid that is used to treat lipid disorders. It is a prodrug, which means that it must be converted to another chemical (fenofibric acid) in the body before it can work.

Fenofibric acid increases the activity of lipoprotein lipase, an enzyme that breaks down triglycerides, a type of fat in the blood. It also affects production, transportation, and storage of triglycerides. Overall benefits of fenofibrate use include a 30%-60% decrease in total blood triglycerides, a modest increase in high density lipoprotein cholesterol (HDL-C, commonly known as "good" cholesterol), and a decrease in low density lipoprotein cholesterol (LDL-C, commonly known as "bad" cholesterol) and total cholesterol.

Fenofibrate products are available in multiple strengths and dosage forms. Fenofibrate formulations are not bioequivalent and are not interchangeable except for generic equivalents. Fenofibrate was approved by the FDA in February 1998.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS:

  • Oral capsules: 50 and 150 mg fenofibrate; 50 and 150 mg Lipofen
  • Oral tablets: 48, 54, 145, and 160 mg fenofibrate; 40 mg Fenoglide; 54 and 160 mg Lofibra; 48 and 145 mg Tricor; 50 and 160 mg Triglide
  • Micronized oral capsules: 30 and 90 mg Antara; 43, 67,130, 134, and 200 mg fenofibrate; 67, 134, and 200 mg Lofibra

STORAGE: Fenofibrate products should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).

PRESCRIBED FOR: Fenofibrate is used with dietary modifications for the treatment of lipid disorders. It helps reduce levels of LDL-C, total cholesterol, triglycerides, and apolipoprotein B, and increase HDL-C. It is prescribed to patients with primary hypercholesterolemia or mixed dyslipidemia, and hypertriglyceridemia.

Medically Reviewed by a Doctor on 11/11/2014

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