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Medical Author:

William C. Shiel Jr., MD, FACP, FACR

William C. Shiel Jr., MD, FACP, FACR

Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

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In this Article

• What is Felty's syndrome?
• What are the symptoms of Felty's syndrome?
• What causes Felty's syndrome?
• How is Felty's syndrome diagnosed?
• How is Felty's syndrome treated?
• Felty's Syndrome At A Glance
• Felty's Syndrome Glossary
• Felty's Syndrome Index
• Find a local Rheumatologist in your town

How is Felty's syndrome treated?

Treatment of Felty's syndrome is not always required. The underlying rheumatoid arthritis is managed in the standard fashion. Treatments used for patients with recurring infections, active arthritis, or ulcer in the legs include rheumatoid disease modifying drugs, such as methotrexate and azathioprine. Patients with severe infectious diseases may benefit by weekly injections with a stimulating factor (granulocyte stimulating factor/GSF) that acts to increase the amount of white blood cells. Surgical removal of the spleen has been performed for the same reasons but has not been evaluated by long-term research studies.

Felty's Syndrome At A Glance

• Felty's syndrome is a complication of long-standing rheumatoid arthritis.
• Patients with Felty's syndrome can have more infections than the average person and can develop leg ulcers.
• The cause of Felty's syndrome is not known.
• Felty's syndrome is diagnosed by the presence of three conditions: rheumatoid arthritis, an enlarged spleen, and an abnormally low white blood count.
• Treatment of Felty's syndrome is not always required, but medications are used for serious manifestations.