Felty's Syndrome
Medical Author: William C. Shiel Jr., MD, FACP, FACR
What is Felty's syndrome?
Felty's syndrome is a complication of long-standing rheumatoid arthritis. Felty's
syndrome is defined by the presence of three conditions: rheumatoid arthritis, an enlarged spleen (splenomegaly),
and an abnormally low white blood count. Felty's syndrome is uncommon. It affects less than 1% of patients with rheumatoid
arthritis.
What are the symptoms of Felty's syndrome?
Some patients with Felty's syndrome have more infections, such as pneumonia or skin
infections, than the average person. This increased susceptibility to infections
is attributed to the low white blood counts that are characteristic of Felty's syndrome. Ulcers in the skin over the legs can complicate
Felty's syndrome.
What causes Felty's syndrome?
The cause of Felty's syndrome is not known. Some patients with rheumatoid arthritis develop Felty's syndrome but most do not. White blood cells are produced in the bone marrow. There
seems to be an active bone marrow function in patients with Felty's syndrome, producing white cells,
despite the low numbers of circulating white blood cells. White cells may be stored excessively in the
spleen of a patient with Felty's syndrome. This is especially true in patients
with Felty's syndrome that have antibodies against the particular type of white blood
cells usually affected (cells called granulocytes or neutrophils).
How is Felty's syndrome diagnosed?
There is no single test for Felty's syndrome. It is diagnosed based
on the presence of the three conditions mentioned above. Most patients do have rheumatoid
arthritis antibodies (rheumatoid factor) in the blood.
How is Felty's syndrome treated?
Treatment of Felty's syndrome is not always required. The underlying rheumatoid arthritis is managed in the standard fashion. Treatments
used for patients with recurring infections, active arthritis, or ulcer in the legs
include rheumatoid disease modifying drugs, such as methotrexate and azathioprine. Patients
with severe infectious diseases may benefit by weekly injections with a
stimulating factor (granulocyte stimulating
factor/GSF) that acts to increase the amount of white blood cells.
Surgical removal of the spleen has been performed for the same
reasons but has not been evaluated by long-term research studies.
- Felty's syndrome is a complication of long-standing rheumatoid arthritis.
- Patients with Felty's syndrome can have more infections than the average person and can develop leg ulcers.
- The cause of Felty's syndrome is not known.
- Felty's syndrome is diagnosed by the presence of three conditions: rheumatoid arthritis, an enlarged spleen, and an abnormally low white blood count.
- Treatment of Felty's syndrome is not always required, but medications are used for serious manifestations.
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- Rheumatoid Factor - Read about the rheumatoid factor (RF) blood test used for the diagnosis of rheumatoid arthritis, lupus and sarcoidosis. Elevated results, or high levels, indicate severe disease. Source:MedicineNet
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Last Editorial Review: 3/27/2008