felodipine, Plendil (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIBED FOR: Felodipine is used to treat high blood pressure. It may be used alone or in combination with other drugs. Felodipine also is used to treat patients with angina although it is not FDA approved for this use.

SIDE EFFECTS: The most common side effects of felodipine are:

Other important side effects include:

  • Overgrowth of gums,
  • rash,
  • upper respiratory tract reactions, and
  • fainting.



PREPARATIONS: Tablets (extended Release): 2.5, 5, and 10 mg

STORAGE: Tablets should be stored below 86 F (30 C) and should be protected from light and moisture.

DOSING: The recommended dose of felodipine is 2.5-10 mg once daily. It should be taken without food or with no more than a light meal since food may reduce its absorption. Since felodipine comes as a sustained-release tablet, it should be swallowed whole. It should not be chewed or crushed.

DRUG INTERACTIONS: Cimetidine (Tagamet), ketoconazole (Nizoral, Extina, Xolegel, Kuric), itraconazole (Sporanox), and erythromycin can block the breakdown of felodipine, resulting in higher blood concentrations of felodipine and drops in blood pressure. Carbamazepine (Tegretol), phenobarbital, or phenytoin (Dilantin) can lower felodipine blood concentrations. Therefore, higher doses of felodipine may be necessary in patients receiving these medications.

Medically Reviewed by a Doctor on 2/24/2015

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