febuxostat, Uloric (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
SIDE EFFECTS: Common reactions to febuxostat include:
Other important, but less common side effects include:
GENERIC AVAILABLE: No
PREPARATIONS: Tablets: 40 and 80 mg
STORAGE: Febuxostat should be stored at room temperature between 15 C to 30 C (59 F to 86 F).
DOSING: The recommended dose is 40 or 80 mg daily. It may be administered with or without food, and it can be taken with antacids. Flares of gout may increase after febuxostat is started as uric acid moves out of tissues. These gout flares may be prevented with non-steroidal anti-inflammatory drugs (for example, indomethacin [Indocin, Indocin-SR]) or colchicine.
DRUG INTERACTIONS: Febuxostat may increase blood levels of mercaptopurine (Purinethol), azathioprine (Imuran), and theophylline (Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin) by reducing their breakdown in the body. Therefore, febuxostat should not be administered with mercaptopurine, azathioprine, and theophylline.
PREGNANCY: There are no adequate studies of febuxostat in pregnant women.
NURSING MOTHERS: It is not known whether febuxostat is excreted in human milk.
Medically reviewed by Eni Williams, PharmD
REFERENCE: FDA Prescribing information for Uloric
Medically Reviewed by a Doctor on 9/11/2015
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