- What is febuxostat, and how does it work (mechanism of action)?
- What brand names are available for febuxostat?
- Is febuxostat available as a generic drug?
- Do I need a prescription for febuxostat?
- What are the side effects of febuxostat?
- What is the dosage for febuxostat?
- Which drugs or supplements interact with febuxostat?
- Is febuxostat safe to take if I'm pregnant or breastfeeding?
- What else should I know about febuxostat?
What is the dosage for febuxostat?
The recommended dose is 40 or 80 mg daily. It may be administered with or without food, and it can be taken with antacids. Flares of gout may increase after febuxostat is started as uric acid moves out of tissues. These gout flares may be prevented with non-steroidal anti-inflammatory drugs (for example, indomethacin [Indocin, Indocin-SR]) or colchicine.
Which drugs or supplements interact with febuxostat?
Febuxostat may increase blood levels of mercaptopurine (Purinethol), azathioprine (Imuran), and theophylline (Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin) by reducing their breakdown in the body. Therefore, febuxostat should not be administered with mercaptopurine, azathioprine, and theophylline.
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