famotidine, Pepcid, Pepcid AC (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DOSING: The recommended adult oral dose for treating duodenal ulcers is 40 mg once daily at bedtime or 20 mg twice daily. Most patients heal their ulcers within 4 weeks. The regimen for maintenance therapy after the ulcers are healed is 20 mg once a day at bedtime. The recommended oral dose for adults with gastric ulcers is, 40 mg once daily at bedtime. Esophagitis is treated with 20 or 40 mg twice daily for up to 12 weeks. Zollinger-Ellison syndrome is treated with 20 mg every 6 hours, and doses up to 160 mg every 6 hours have been used in some patients. GERD is treated with 20 mg twice daily for up to 6 weeks. Occasional heartburn is treated with 10-20 mg daily administered 15 to 60 minutes before ingestion of food or beverages that cause heartburn.

DRUG INTERACTIONS: Famotidine, like other drugs that reduce stomach acid, may interfere with the absorption of drugs that require acid for adequate absorption. Examples include iron salts (for example iron sulphate), itraconazole (Sporanox), and ketoconazole (Nizoral, Extina, Xolegel, Kuric).

PREGNANCY: Use of famotidine during pregnancy has not been adequately evaluated.

NURSING MOTHERS: Famotidine is secreted into breast milk. Due to the potential but unknown harm that famotidine might cause to the infant, nursing mothers should consider discontinuing famotidine.

SIDE EFFECTS: Side effects of famotidine are rare. Minor side effects include constipation, diarrhea, fatigue, headache, insomnia, muscle pain, nausea, and vomiting. Major side effects include agitation, anemia, confusion, depression, easy bruising or bleeding, hallucinations, hair loss, irregular heartbeat, rash, visual changes, and yellowing of the skin or eyes (jaundice).

Reference: FDA Prescribing Information


Last Editorial Review: 1/4/2012



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