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- What is exenatide, and how does it work (mechanism of action)?
- What brand names are available for exenatide?
- Is exenatide available as a generic drug?
- Do I need a prescription for exenatide?
- What are the side effects of exenatide?
- What is the dosage for exenatide?
- Which drugs or supplements interact with exenatide?
- Is exenatide safe to take if I'm pregnant or breastfeeding?
- What else should I know about exenatide?
What is exenatide, and how does it work (mechanism of action)?
Exenatide is an injectable drug that reduces the level of sugar (glucose) in the blood. It is used for treating type 2 diabetes. Exenatide belongs in a class of drugs called incretin mimetics because these drugs mimic the effects of incretins. Incretins, such as human-glucagon-like peptide-1 (GLP-1), are hormones that are produced and released into the blood by the intestine in response to food. GLP-1 increases the secretion of insulin from the pancreas, slows absorption of glucose from the gut, and reduces the action of glucagon. (Glucagon is a hormone that increases glucose production by the liver.) All three of these actions reduce levels of glucose in the blood. In addition, GLP-1 reduces appetite. Exenatide is a synthetic (man-made) hormone that resembles and acts like GLP-1. In studies, exenatide-treated patients achieved lower blood glucose levels and experienced weight loss. Exenatide was approved by the FDA in May 2005.
What brand names are available for exenatide?
Is exenatide available as a generic drug?
GENERIC AVAILABLE: No.
Do I need a prescription for exenatide?
What are the side effects of exenatide?
The most common side effects of exenatide are:
- nausea (nausea from exenatide is more common with the higher doses and decreases over time.)
- hypoglycemia (excessively low blood glucose),
- nervousness and,
- stomach discomfort.
Other important side effects include:
There have been reports of acute pancreatitis associated with the use of exenatide. Patients developing severe, persistent abdominal pain should seek prompt medical attention. If pancreatitis is suspected, exenatide should be discontinued and not started again until pancreatitis has been excluded.
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